ProZ.com global directory of translation services
 The translation workplace
Ideas
KudoZ home » English » Medical (general)

frank vs. direct toxicity

English translation: clinically evident vs. direct toxicity ( not directly comparable)

Login or register (free and only takes a few minutes) to participate in this question.

You will also have access to many other tools and opportunities designed for those who have language-related jobs
(or are passionate about them). Participation is free and the site has a strict confidentiality policy.
18:50 May 7, 2009
English to English translations [PRO]
Medical - Medical (general) / toxicity of medication
English term or phrase: frank vs. direct toxicity
frank toxicity of a drug
direct toxicity of a drug

Are they synonyms?
Allda
Local time: 19:32
English translation:clinically evident vs. direct toxicity ( not directly comparable)
Explanation:
These two terms are not synonyms although they are related. Frank toxicity is clinically evident ( producing signs&symptoms) as opposed to concealed.

Direct toxicity's counterpart is indirect toxicity. Both the direct and the indirect toxicity can be frank.

A direct toxicity effect refers to an adverse response to an excess of a particular substance when the response is directly caused by that substance ( not via an additional step as in indirect toxicity). It can be frank.


Selected response from:

lirka
Austria
Local time: 19:32
Grading comment
Thanks once again:-) Your explanation is very clear.
4 KudoZ points were awarded for this answer



Summary of answers provided
3 +1clinically evident vs. direct toxicity ( not directly comparable)lirka
3 +1toxicidad clínica/sintomática // toxicidad directa
Marina Menendez
Summary of reference entries provided
liz askew

  

Answers


5 mins   confidence: Answerer confidence 3/5Answerer confidence 3/5 peer agreement (net): +1
toxicidad clínica/sintomática // toxicidad directa


Explanation:
-frank
Etymology: L, francus.

(medical def)- obvious or clinically evident, such as the unequivocal presence of a condition or a disease. An example is frank bleeding.


--------------------------------------------------
Note added at 9 mins (2009-05-07 19:00:03 GMT)
--------------------------------------------------

http://medical-dictionary.thefreedictionary.com/Frank





--------------------------------------------------
Note added at 2 hrs (2009-05-07 21:37:52 GMT)
--------------------------------------------------

"frank toxicity" can also be translated as "toxicidad evidente".

The definition in English clarifies the meaning of "frank" in the medical field.




Toxicidad evidente es un término general que describe signos claros de toxicidad tras la administración de una sustancia. Estos signos deben ser suficientes para la evaluación del riesgo y deben ser tales que, ante un aumento de la dosis administrada, pueda esperarse la aparición de signos tóxicos graves y una mortalidad probable.
http://www.grupoprevenir.es/normativas/c/eti7Vb.htm




--------------------------------------------------
Note added at 3 hrs (2009-05-07 21:50:12 GMT)
--------------------------------------------------

Sorry, I didn't realize it was an English-English query.

So, "frank" in this case refers to (toxicity) based in "evidence" (that's why it's 'clinical'). It depends on the patient's peculiar reaction to a drug.

Marina Menendez
Argentina
Local time: 14:32
Specializes in field
Native speaker of: Native in SpanishSpanish

Peer comments on this answer (and responses from the answerer)
agree  MPGS: :)
1 min
  -> muchas gracias ; )

neutral  liz askew: sorry, but what help is this as it is an English-English query?
37 mins
Login to enter a peer comment (or grade)

4 hrs   confidence: Answerer confidence 3/5Answerer confidence 3/5 peer agreement (net): +1
clinically evident vs. direct toxicity ( not directly comparable)


Explanation:
These two terms are not synonyms although they are related. Frank toxicity is clinically evident ( producing signs&symptoms) as opposed to concealed.

Direct toxicity's counterpart is indirect toxicity. Both the direct and the indirect toxicity can be frank.

A direct toxicity effect refers to an adverse response to an excess of a particular substance when the response is directly caused by that substance ( not via an additional step as in indirect toxicity). It can be frank.




lirka
Austria
Local time: 19:32
Specializes in field
Native speaker of: Native in EnglishEnglish, Native in SlovenianSlovenian
PRO pts in category: 43
Grading comment
Thanks once again:-) Your explanation is very clear.
Notes to answerer
Asker: T H A N K Y O U !!! :-))


Peer comments on this answer (and responses from the answerer)
agree  Jörgen Slet
4 days
Login to enter a peer comment (or grade)




Reference comments


45 mins peer agreement (net): +1
Reference

Reference information:
in case this helps

The basis of toxicity testing - Google Books Result
by Donald J. Ecobichon - 1997 - Medical - 220 pages
Since, by experimental design, the highest dosage should elicit toxicity, at least one treatment level should produce frank (overt) effects, the Frank ...
books.google.co.uk/books?isbn=0849385547...

frank = overt
?

--------------------------------------------------
Note added at 46 mins (2009-05-07 19:36:08 GMT)
--------------------------------------------------

The characterization of immunotoxicity must consider the impact of overt toxicity (e.g., effects on the
immune system are not the direct effects of test article treatment, but are indirect effects mediated
via stress and/or other dose-related responses)

--------------------------------------------------
Note added at 48 mins (2009-05-07 19:38:25 GMT)
--------------------------------------------------

Review: stimulants improve overt and covert aggression related ...
Outcomes included overt (resulting in a direct confrontation with others) and covert (hidden from others) aggression related behaviours. Main results ...
ebmh.bmj.com/cgi/content/full/5/4/108 - Similar pages
by RG Klein - 2002

--------------------------------------------------
Note added at 49 mins (2009-05-07 19:39:33 GMT)
--------------------------------------------------

so
based on the findings I would say "frank" i.e. "overt" and "direct" are synonyms.

But don't quote me.

--------------------------------------------------
Note added at 50 mins (2009-05-07 19:40:27 GMT)
--------------------------------------------------

Main Entry: overt
Part of Speech: adjective
Definition: obvious, unconcealed
Synonyms: apparent, clear, definite, manifest, observable, open, patent, plain, public, undisguised, visible
Notes: covert (concealed, covered, hidden) is the opposite of overt (apparent, open to view, plain, public)
overt means apparent or open to view or plain or public; avert means to prevent or turn awa

--------------------------------------------------
Note added at 14 hrs (2009-05-08 09:14:20 GMT)
--------------------------------------------------

see this too

overt = direct

http://209.85.229.132/search?q=cache:51PMDCn04cEJ:www.proz.c...

--------------------------------------------------
Note added at 14 hrs (2009-05-08 09:18:57 GMT)
--------------------------------------------------

Environmental Toxicology: Current Developments - Google Books Result
by John Rose - 1998 - Science - 397 pages
Direct or "frank" toxicity. In some cases, uptake of neurotoxic elements leads to clinically diagnosed conditions. For example, prolonged exposure to ...
books.google.co.uk/books?isbn=905699140X...

liz askew
United Kingdom
Specializes in field
Native speaker of: Native in EnglishEnglish
PRO pts in category: 76
Note to reference poster
Asker: thanks, Liz!


Peer comments on this reference comment (and responses from the reference poster)
agree  Laura Massara
1 hr
Login to enter a peer comment (or grade)




Return to KudoZ list


KudoZ™ translation help
The KudoZ network provides a framework for translators and others to assist each other with translations or explanations of terms and short phrases.



See also: