nonpareil beads or seeds

Spanish translation: perlas o esferas de azucar y almidon

13:59 Jul 5, 2005

English to Spanish translations [PRO]

English term or phrase: nonpareil beads or seeds

in the context of pharmaceutical dosages

hecdan (X) KudoZ activity Questions: 24 (none open) (1 closed without grading) Answers: 3553
Local time: 13:42

Spanish translation:perlas o esferas de azucar y almidon

Explanation:
nonpareil- here: made of sugar and starch

In this case the beads are covered with a layer of active substance:

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Sugar-starch beads are also known as nonpareil seeds and are used in confectionery as well as in pharmacy. They are generally spheroidal in shape. A typical composition is about 65% cane sugar and about 35% corn starch. Beads of 20-25 mesh (0.84-0.71 mm. in diameter) are preferred. The beads serve as nuclei for application of the first coat of drug and drug-binding substance. (See link below)
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Selected response from:

Davorka Grgic
Local time: 18:42

Grading comment

4 KudoZ points were awarded for this answer

Summary of answers provided

4 +5

perlas o esferas de azucar y almidon

Davorka Grgic

4 +2

Nonpareil

Felicite Robertson

bolita de azucar

jeff robson

cuentas/esferas/gránulos/perlas o semillas de azúcar (nonpareils)

Marocas

píldoras con particulas de liberación moderada

starlight

Discussion entries: 5

Answers

32 mins confidence:

peer agreement (net): +5

perlas o esferas de azucar y almidon

Davorka Grgic
Local time: 18:42
Native speaker of:

Croatian,

Spanish
PRO pts in pair: 905

34 mins confidence:

peer agreement (net): +2

Nonpareil

Explanation:
Sugar-starch beads are also known as nonpareil seeds and are used in confectionery as well as in pharmacy. They are generally spheroidal in shape. A typical composition is about 65% cane sugar and about 35% corn starch. Beads of 20-25 mesh (0.84-0.71 mm. in diameter) are preferred. The beads serve as nuclei for application of the first coat of drug and drug-binding substance.

Felicite Robertson
United Kingdom
Local time: 17:42
Native speaker of:

French,

English
PRO pts in pair: 132

44 mins confidence:

bolita de azucar

Explanation:
nonpareil \non-puh-REL\, adjective:
Having no equal; peerless.

noun:
1. Something of unequaled excellence; a peerless thing or person.
2. A flat disk of chocolate covered with beads of colored sugar.

During the winter following the gathering, the capers are graded by size by passing through sieves. The seven chief classifications are--"Nonpareil" (smallest), "Surfine," "Capucine," "Capote," "Fine," "Mi-fine," and "Commune" (largest). After grading, they are replaced in barrels of vinegar and thus preserved until sold. Before shipment, they are washed in vinegar of a standard of 12°, which renders them quite firm, and placed in barrels without vinegar, the finer qualities to be repacked in bottles, etc.
http://digital.lib.msu.edu/projects/cookbooks/books/grocerse...

The purpose of this work was to investigate drug release from film-coated chlorpheniramine maleate (CPM) nonpareils (sugar spheres) and the effect of water influx on the drug release mechanism.
Pharm Dev Technol. 1999;4(4):481-90

jeff robson
Native speaker of:

English
PRO pts in pair: 14

53 mins confidence:

cuentas/esferas/gránulos/perlas o semillas de azúcar (nonpareils)

Explanation:
beads son cuentas/esferas/gránulos/perlas
seeds = semillas
non-pareil = Nonpareil® (marca registrada)

En el contexto farmacológico: «Nonpareil es el nombre comercial de ciertos gránulos esféricos de composición diversa (azúcar, almidón de maíz o una combinación de ambos). Se emplean en algunas formas farmacéuticas de liberación controlada. Se clasifican según el tamaño y composición (p. ej., Nonpareil-101; Nonpareil-103). A estos núcleos se los recubre con el principio activo de interés, por ejemplo, el bermoprofeno.
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Nonpareil - Del Webster’s: «a small pellet of multicolored sugar for decorating canday, cake, or cookies».
http://medtrad.iwhome.com/medtradiario/defsN.htm

CPM) **nonpareils (sugar spheres)** and the effect of water influx on the drug release mechanism ... sists of a drug loaded on the surface of a sugar nonpareil ...
taylorandfrancis.metapress.com/ index/ED2ATWHMV50P1VHU.pdf -

Stability testing of morphine sulfate formulated with **nonpareil sugar seeds (consisting of sucrose and starch)** and fumaric acid revealed the formation of the three impurities 5-(hydroxymethyl)-2-furfural, 10-hydroxymorphine and 10-oxomorphine.
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....and its formation in the presence of morphine sulfate formulated with fumaric acid suggests that caution should be exercised when including **nonpareil seeds** in formulations that contain acidic drug salts and/or acid excipients.
www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve& db=PubMed&list_uids=12587110&dopt=Abstract

Marocas
Venezuela
Local time: 12:42
Native speaker of:

Spanish
PRO pts in pair: 2885

1 hr confidence:

píldoras con particulas de liberación moderada

Explanation:
Por lo que leí en AAPS(AMERICAN ASSOCIATION OF PHARMACEUTICAL SCIENCES)pienso que ese puede ser el significado. Suerte !!

starlight
Local time: 11:42
Native speaker of:

Spanish
PRO pts in pair: 462

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