serial stradobodies

Russian translation: страдотела с сериями тандемных доменных повторов

09:36 Mar 1, 2015
English to Russian translations [PRO]
Science - Biology (-tech,-chem,micro-)
English term or phrase: serial stradobodies
Nagashima et al. (Journal of Bioscience and Bioengineering 111(4): 391-6 (2011) and Molecular Immunology 45(10):2752-63 (2008)) described "serial stradobodies" with tandem repeats of Fc domains, as anticipated by WO 2008/151088, which resulted in enhanced ADCC relative to the parent monoclonal antibodies from which they were derived, i.e. comprising the identical Fab region.


a multimerizing serial stradobody comprises both one or more multimerization domains and one or more domain linkages.


These other stradobodies include the GB3500 "series" directed against EGFR, the GB4500 "series" directed against CD20, and the GB7500 series directed against TNF.

как перевести serial stradobodies и series?

Серийные?
dao2812
Russian translation:страдотела с сериями тандемных доменных повторов
Explanation:
А то буквальный перевод наводит на мысли о серийных убийцах :-)
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Natalie
Poland
Local time: 19:40
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Summary of answers provided
4страдотела с сериями тандемных доменных повторов
Natalie
4дочерние (производные) антитела
NataliiaK
3серийные страдотела
Andrey Svitanko


  

Answers


2 hrs   confidence: Answerer confidence 3/5Answerer confidence 3/5
серийные страдотела


Explanation:
series - серия

Пожалуй все-таки так. Хотя найти этого не выйдет, в гугле такого нет на русском
Только тут по картинкам можно попрыгать, схематично показано
http://www.google.com/patents/US20140072582

Andrey Svitanko
Poland
Local time: 19:40
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PRO pts in category: 539
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6 hrs   confidence: Answerer confidence 4/5Answerer confidence 4/5
страдотела с сериями тандемных доменных повторов


Explanation:
А то буквальный перевод наводит на мысли о серийных убийцах :-)

Natalie
Poland
Local time: 19:40
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Native speaker of: Russian
PRO pts in category: 4329
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7 hrs   confidence: Answerer confidence 4/5Answerer confidence 4/5
дочерние (производные) антитела


Explanation:
из патента http://www.freshpatents.com/-dt20140313ptan20140072582.php
FIG. 17 shows the binding of the parent antibody (родительское, исходное антитело) GB2500 or the indicated serial stradobody (определенного (дочернего) производного страдотела) to FcγRIIIa. GB2500 (grown in HEK or CHO cells) was tested at concentrations ranging from 3333-208 nM. Serial stradobodies GB2524, GB2538, GB2540, GB2542, GB2554, and GB2555 were tested at concentrations ranging from 200-12.5 nM.
Обратите внимание на формирование нумерации GB2500 - родительское антитело, а затем изменяеться только последние 2 значения (потому, что антитела являються вторичными, производными от первого, т.к. специфичность родительского антитела НЕ меняеться, а меняеться только КОНСТАНТНЫЙ регион).
Также, в случае

NataliiaK
Ukraine
Local time: 20:40
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Native speaker of: Native in UkrainianUkrainian, Native in RussianRussian
PRO pts in category: 139
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