GLOSSARY ENTRY (DERIVED FROM QUESTION BELOW) | ||||||
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01:44 Aug 13, 2002 |
English language (monolingual) [Non-PRO] Medical - Biology (-tech,-chem,micro-) / biology of cartilage matrix | ||||
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| Selected response from: Karina Pelech | |||
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SUMMARY OF ALL EXPLANATIONS PROVIDED | ||||
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5 +3 | see explanation |
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3 | You could probably get away with "souris KO" |
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see explanation Explanation: knock-out refers to the genes that code for specific functions within the genome, which are replaced by other genes in a controlled manner to alter the function of the specific gene being monitored or investigated. Hope this helps Good luck. -------------------------------------------------- Note added at 2002-08-13 01:53:42 (GMT) -------------------------------------------------- \"A new technique overcame these limitations and opened up a whole world of possibilities for making almost any wished-for animal model. It is called homologous recombination, or more loosely, gene targeting, and it is awesomely precise. In homologous recombination, a desired gene finds an identical, or homologous, sequence of DNA in the animal\'s genome and swaps places with it. Homologous recombination allows scientists to carry out a new type of research with transgenic mice: knockout experiments, in which a native gene is eliminated by replacing it with a defective gene. \" \"**Knockout**\" mice: Experimental mice created by disrupting the function of a specific gene.\" Reference: http://www.hhmi.org/genetictrail/g100.html |
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