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spend, spent

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07:15 Aug 11, 2012

English to English translations [PRO]
Medical - Mathematics & Statistics / clinical trials

English term or phrase: spend, spent

All statistical type I error will be spent on the hypothesis tests performed on the data collected in the treatment period
[what does it mean in this context?]

kgas

Summary of answers provided

eliminated

B D Finch

3 +1

use a spending function

DLyons

3 -1

passed on

Erich Ekoputra

Summary of reference entries provided
might help	MCristy

Answers

7 mins confidence:

peer agreement (net): -1

spent passed on

Explanation:

The errors of Type I will be passed on to the test, i.e. made as input for tjhe said test.

Erich Ekoputra
Indonesia
Local time: 16:14
Native speaker of:

Indonesian

1 hr confidence:

eliminated

Explanation:
It means that Type 1 errors (i.e. those leading to rejection of a true null hypothesis) will be eliminated by means of the tests in question.

B D Finch
France
Local time: 11:14
Native speaker of:

English
PRO pts in category: 4

3 hrs confidence:

peer agreement (net): +1

use a spending function

Explanation:
Probably arising in the context of deciding whether to stop the trial early.

Reference: http://books.google.ie/books?id=KW9esgo759EC&pg=PA217&lpg=PA...
Reference: http://www.niaid.nih.gov/about/organization/dcr/BRB/Document...

DLyons
Ireland
Local time: 10:14
Specializes in field
Native speaker of:

English
PRO pts in category: 8

Reference comments

5 hrs

Reference: might help

Reference information:
There are two ways of designing an O'Brien-Fleming design, a popular design for conducting interim analyses of clinical trials. The first method is to use an error (or alpha) spending function, which essentially gives you a "budget" of error you can spend at each interim analysis.
http://realizationsinbiostatistics.blogspot.ro/2007/09/my-ob...

Lan and DeMets developed a very flexible
boundary procedure that accommodates unequal
timing, additional looks, even extending the trial
– Called “alpha spending” functions
– Researchers can choose to “spend” their alpha (i.e.,
conduct interim analyses) any way they want
– Ensures that total alpha “spent” is no more than 0.05
(or whatever was specified)
http://www.icssc.org/Documents/AdvBiosGoa/Tab 25.00_InterimA...

MCristy
Romania
Native speaker of:

Romanian

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