KudoZ home » English » Medical: Pharmaceuticals

Tolerability

English translation: tolerability [= tolerabilidad, tolerance = tolerancia, efficacy = eficacia, effectiveness = efectividad]

Login or register (free and only takes a few minutes) to participate in this question.

You will also have access to many other tools and opportunities designed for those who have language-related jobs
(or are passionate about them). Participation is free and the site has a strict confidentiality policy.

GLOSSARY ENTRY (DERIVED FROM QUESTION BELOW)

English term or phrase:	Tolerability
English translation:	tolerability [= tolerabilidad, tolerance = tolerancia, efficacy = eficacia, effectiveness = efectividad]
Entered by:	liz askew

Options:
- Contribute to this entry
- Include in personal glossary

18:40 Jun 16, 2010

English to English translations [PRO]
Medical - Medical: Pharmaceuticals

English term or phrase: Tolerability

I'm working on a Spanish to English translation that already includes a title in English that contains the word "tolerability."

I would use "tolerance" as "tolerability" does not exist in dictionaries including Merriam-Webster. Do you agree?

The same situation exists for "effectiveness" and "efficacy." I would use "effectiveness." I'm thinking that the title was originally translated from another language into English.

Should I use tolerance and effectiveness and let the customer know? Or should I use their terms, but warn the customer? Or am I wrong?

Thanks for your help

Idalia Martin KudoZ activity Questions: 1 (none open) Answers: 25 United States
Local time: 21:03

tolerabilidad = tolerability, tolerancia = tolerance, eficacia = efficacy, efectividad -

Explanation:
effectiveness

según sepa

--------------------------------------------------
Note added at 17 mins (2010-06-16 18:57:52 GMT)
--------------------------------------------------

this is what I have encountered in verbatims on clinical trials from Spanish into English.

Selected response from:

liz askew
United Kingdom
Local time: 03:03

Grading comment

Thanks for your comprehensive help.
4 KudoZ points were awarded for this answer

Summary of answers provided

4 +7

tolerabilidad = tolerability, tolerancia = tolerance, eficacia = efficacy, efectividad -

liz askew

5 +2

tolerability

Alexander Chisholm

resistencia

caminante7

(Drug) Tolerance

ARS54

Summary of reference entries provided
	liz askew

Discussion entries: 10

liz askew

United Kingdom

19:28 Jun 23, 2011

@Alexander. Thanks..just wanted this noted in case anybody in future comes looking...

Alexander Chisholm

No problem

19:25 Jun 23, 2011

happens.

liz askew

United Kingdom

18:42 Jun 23, 2011

Grovel, grovel....several months on, I think I was incorrect here!!!

see this discussion:

http://www.proz.com/kudoz/french_to_english/medical:_pharmac...

From further research, "eficacia, tolerancia y seguridad" are used in Sp. so "eficacia = efficacy, tolerancia = tolerability and "seguridad = safety.

Any comments from anybody?

MMUlr

Germany

Caution: effectiveness - efficacy

04:08 Jun 17, 2010

As some of the contributors mentioned already, pls. be careful about confusing these terms:
e.g., http://www.australianprescriber.com/magazine/23/6/114/5/

Idalia Martin

United States

ASKER

No wonder!

00:06 Jun 17, 2010

I had looked up tolerability and efficacy in www.merriam-webster.com and didn't find it. I went back to see why not...I had it on the "Thesaurus" option.

liz askew

United Kingdom

22:05 Jun 16, 2010

sorry....that should read "...translation...". Sure this is an English into English query, but based on the facts before us "tolerability" should not be changed. Obviously I had not made myself 100% clear, although I did have 4 peers vote for my answer, but one peer who did not:)

liz askew

United Kingdom

22:03 Jun 16, 2010

In case I have not made myself clear. Tolerability, tolerance, effectiveness, efficacy all exist in English in the pharmaceutical field. Likewise in Spanish, "tolerabilidad", "tolerancia", "efectividad", "eficacia". They should be kept as separate terms in both languages. If you are doing a Spanish into English transaltion and you have the word "tolerability" then keep it as such.

ARS54

Italy

You're right, Idalia:->

19:40 Jun 16, 2010

"tol·er·ance (tlr-ns)
n.
...

2. (MEDICAL) The capacity to absorb a drug continuously or in large doses without adverse effect; diminution in the response to a drug after prolonged use.
... ,

and:-

http://www.google.it/search?hl=it&newwindow=1&q="tolerance" ...

:-))

liz askew

United Kingdom

19:04 Jun 16, 2010

Idalia
http://mw4.merriam-webster.com/dictionary/tolerance
http://mw2.merriam-webster.com/dictionary/effectiveness

lorenab23

United States

Idalia

18:54 Jun 16, 2010

Can you give us the original context in Spanish? I can tell you that "tolerability" is widely use in Medicine
and they are both define by Merriam-Webster
http://www.merriam-webster.com/dictionary/tolerability
http://www.merriam-webster.com/dictionary/efficacy

Answers

16 mins confidence:

peer agreement (net): +7

tolerabilidad = tolerability, tolerancia = tolerance, eficacia = efficacy, efectividad -

liz askew
United Kingdom
Local time: 03:03
Meets criteria
Works in field
Native speaker of:

English
PRO pts in category: 8

Grading comment

Thanks for your comprehensive help.

Notes to answerer

Asker: Thanks, Liz for all your time and help. It was very clear.

Peer comments on this answer (and responses from the answerer)

agree

Pablo Jimenez

4 mins

-> Gracias! Phew!

agree

Emma Goldsmith: You're definitely right. It would be a mistake for Idalia to change these words

24 mins

-> Nice to know I have been right in my translations of clinical trial spreadsheets too!

agree

Ildiko Santana: I can't comment on the Spanish terms, but I can confirm that neither tolerance/tolerability, nor effectiveness/efficacy are interchangeable.

41 mins

-> Thank you! Exactly the point I am making, and the references in the reference box confirm this.

agree

Jorge Arteaga M.D.

1 hr

-> Thank you!

disagree

Alexander Chisholm: definitely not effectiveness - that's efficacy - tolerability is one of the safety parameters.

1 hr

-> I do not understand your comment. "Eficacia" = efficacy. "Efectividad" = effectiveness. My answer states that there are separate words in Spanish for "efficacy, effectiveness, tolerability, and tolerance" and these are not to be confused. So?

agree

Rachel Fell: maybe the prob. is the way your answer's set out in total -?\\Looks clear now, on revisiting!

3 hrs

-> Thank you! Clear enough to me.

agree

J Celeita: Liz I didn't get it...can you explain it again please? =-) j/k

3 hrs

-> Ha ha!! I only bend over backwards once:) Thank you!

agree

fvasconcellos: Spot on. Tolerability and tolerance are completely different concepts, as are the three "E"s (effectiveness, efficacy, and efficiency)

5 hrs

-> Thank you very much, we have all put jam on it:)

agree

Goldcoaster

12 hrs

-> Thank you!

41 mins confidence:

tolerability resistencia

Explanation:
Here is my suggestion.
Resistencia y efectividad.

caminante7
United States
Local time: 19:03
Does not meet criteria
Native speaker of: Spanish

Notes to answerer

Asker: Gracias, Caminanante7

1 hr confidence:

peer agreement (net): +2

tolerability tolerability

Explanation:
Definitely tolerability.
Means the ability of a drug or other substance to be tolerated by the body.
In a clinical study there are 2 main aims:
1. to evaluate the efficacy of an IMP
2. to evaluate the safety and tolerability of the IMP

I am a senior medical writer, writing Study Protocols and Clinical Study Reports and this is the termused all the time in this field.

Example sentence(s):

Safety and Tolerabilty of Repeat Dosing of GSK233705/GW642444 in COPD
This is a Phase IIIb, multi-center, open label, randomized, study that compares the safety and tolerabilty of Intravenous Ferric Carboxymaltose(FCM) vs. standard medical care in postpartum and heavy uterine bleeding subjects with iron deficiency

Reference: http://clinicaltrials.gov/ct2/show/NCT00749411
Reference: http://www.centerwatch.com/clinical-trials/listings/studylis...

Alexander Chisholm
Local time: 04:03
Meets criteria
Specializes in field
Native speaker of:

English
PRO pts in category: 2

Notes to answerer

Asker: Thank you, Alexander

17 mins confidence:

(Drug) Tolerance

Explanation:
http://www.medical-dictionary.thefreedictionary.com/toleranc...

http://www.google.it/search?hl=it&source=hp&q="Drug toleranc...

...And see here for effectiveness and efficacy ->

Australian Prescriber - Efficacy, effectiveness, efficiency - [ Traduci questa pagina ]Efficacy is not the same as effectiveness.1 A treatment is effective if it works in real life in non-ideal circumstances. In real life, medications will be ...
www.australianprescriber.com/.../23/6/.../5/ - Australia

--------------------------------------------------
Note added at 14 ore (2010-06-17 09:35:09 GMT)
--------------------------------------------------

...to you, too, dear, :)

--------------------------------------------------
Note added at 1 giorno5 ore (2010-06-18 00:22:10 GMT)
--------------------------------------------------

...A very interesting article about the (very recent) use of the term *tolerability* in the medical literature:-

BMJ 2000;321:77 ( 8 July )

TOLERATING 'TOLERABILITY'
Karin R M Band and David Winstanley, freelance medical translators.

"Until recently, the English language lacked a single, punchy, positively flavoured noun to describe a medicine's (greater or lesser) freedom from side effects. Whereas German has its Verträglichkeit (from sich vertragento agree with something or someone), a word that emphasises the positive aspect of something being well tolerated, all that could be found in English was more or less verbose phraseology, such as a good side effect profile, without any irritant effect, etc, invariably dragging in the idea of something adversenot only clumsy, but, surely, a pharmaceutical copywriter's nightmare. Quite obviously, this was a void that needed filling.
And filled it has been, to a large extent, by the adoption, **over the last 10 years or so**, of 'tolerability' ... "
http://www.bmj.com/cgi/content/extract/321/7253/77

And: "... The term tolerability refers to, ... , **acceptability as measured by side-effects** ... tolerance ..." - www.nice.org.uk

Example sentence(s):

...This study suggests that drug tolerance may be an important determinant of the ... In some patients, ...
Medication and Drugs question: What is tolerance in drugs? ...

Reference: http://www.ncbi.nlm.nih.gov
Reference: http://www.wiki.answers.com

ARS54
Italy
Local time: 04:03
Does not meet criteria
Specializes in field
Native speaker of:

Italian

Notes to answerer

Asker: Thank you, ARS54

Reference comments

10 mins

Reference

Reference information:
Hi

All I can tell you is that I have translated texts from Sp-En and encountered "eficacia" = efficacy and "efectividad" = effectiveness.

Principios de epidemiología del medicamento - Capítulo 1
- [ Translate this page ]
by DELOSMA LA CONTRIBUCIÓN - Related articles
Análogamente, la efectividad de un fármaco en la práctica no sólo dependerá de su eficacia «intrínseca» -demostrada en el contexto de un ensayo clínico- ...
www.icf.uab.es/pem/cap1.asp - Cached - Similar

--------------------------------------------------
Note added at 12 mins (2010-06-16 18:53:13 GMT)
--------------------------------------------------

see this too:

http://forum.wordreference.com/showthread.php?t=1306358

--------------------------------------------------
Note added at 14 mins (2010-06-16 18:54:43 GMT)
--------------------------------------------------

tolerabilidad seems to be used in Spanish

http://www.google.co.uk/search?q=tolerabilidad fármacos&hl=e...

--------------------------------------------------
Note added at 15 mins (2010-06-16 18:55:42 GMT)
--------------------------------------------------

tolerabilidad Vs tolerancia (en medicina) - WordReference Forums
- [ Translate this page ]
4 posts - 3 authors
tolerabilidad Vs tolerancia (en medicina) Medical Terminology.
forum.wordreference.com › ... › Medical Terminology - Cached - Similar

liz askew
United Kingdom
Meets criteria
Works in field
Native speaker of:

English
PRO pts in category: 8

Note to reference poster

Asker: Thanks, Liz

Return to KudoZ list

Changes made by editors

Jun 18, 2010 - Changes made by liz askew:
Edited KOG entry	liz askew's old entry - "Tolerability" => "tolerabilidad = tolerability///[tolerancia = tolerance, eficacia = efficacy, efectividad]"
Jun 18, 2010 - Changes made by liz askew:
Created KOG entry	KudoZ term => KOG term
Jun 16, 2010 - Changes made by philgoddard:
Language pair	Spanish to English => English

KudoZ™ translation help
The KudoZ network provides a framework for translators and others to assist each other with translations or explanations of terms and short phrases.

Overview

Latest translation questions

Ask a translation question

See also:

ProZ.com term search

Search millions of term translations

Tolerability

English translation: tolerability [= tolerabilidad, tolerance = tolerancia, efficacy = eficacia, effectiveness = efectividad]

Login or register (free and only takes a few minutes) to participate in this question.

Answers

Reference comments

Sign in to your ProZ.com account...

Or create a new account

ProZ.com ideas

KudoZ™ translation help
The KudoZ network provides a framework for translators and others to assist each other with translations or explanations of terms and short phrases.

Tolerability

English translation: tolerability [= tolerabilidad, tolerance = tolerancia, efficacy = eficacia, effectiveness = efectividad]

Login or register (free and only takes a few minutes) to participate in this question.

Answers

Reference comments

Sign in to your ProZ.com account...

Or create a new account

ProZ.com ideas

KudoZ™ translation helpThe KudoZ network provides a framework for translators and others to assist each other with translations or explanations of terms and short phrases.

KudoZ™ translation help
The KudoZ network provides a framework for translators and others to assist each other with translations or explanations of terms and short phrases.