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Medical - Medical: Pharmaceuticals / analytical procedure | | English term or phrase: with a known "use at" value as active moiety | This is the analytical procedure for the determination of ascorbic acid in XXX tablets. Section "Reagents and Material" reads:
Ascorbic Acid Reference Standard with a known "use at" value as active moiety
Mobile Phase А 97:3 (v/v) - 25 mM phosphate buffer, pH 3.0: methanol
Mobile Phase B 20:80 (v/v) - water: methanol
Extraction Solvent 20:80 (v/v): 0.25 % (w/v) sodium bisulfite in water: methanol
Can onyone explain in a digestible way "with a known "use at" value"?
Thanks in advance! |
| GEKAMONKudoZ activityQuestions: 259 ( 1 open) ( 4 without valid answers) ( 3 closed without grading) Answers: 1
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| Reference: not much help but...
Reference information:
Well, I understand your difficulty! especially as I can find only two hits for your phrase. In any case it is not "normal English" in my opinion.
I understand that the acid is being used as an active moiety.
Are there established values currently in use that need to be applied when this acid is being used as an active moiety/ingredient.
This is my understanding.
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Note added at 1 hr (2011-01-29 16:57:37 GMT)
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Ascorbic acid (PIM 046)
Ascorbic acid has pKa values of 4.2 and 11.6. Ascorbic acid has a melting temperature of 190°C with decomposition (Moffat, 1986). A solution of ascorbic ...
www.inchem.org/documents/pims/pharm/ascorbic.htm - Cached - Similar
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Note added at 1 hr (2011-01-29 16:58:37 GMT)
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Acid dissociation constant - Wikipedia, the free encyclopedia
To obtain the pKa value for use with aqueous solutions it has to be extrapolated ..... H2A = L-(+)-Ascorbic Acid, H2A is in equilibrium with HA− + H+, 4.17 ...
Theoretical background - Definitions - Equilibrium constant
en.wikipedia.org/wiki/Acid_dissociation_constant - Cached - Similar
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Note added at 1 hr (2011-01-29 17:00:39 GMT)
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Effect of surfactants on the dissociation constants of ascorbic ...
by PV Jaiswal - 2005 - Cited by 10 - Related articles
... group in position 3 is acidic (pKa1 = 4.2), the hydroxyl in position 2 has pKa2 = 11.6, ... It has been recognized that the magnitude of the apparent pKa, View the MathML source ... is the intrinsic interfacial pKa of the prototropic moiety, ... a Literature values for ascorbic acid and maleic acids are 4.10, ...
linkinghub.elsevier.com/retrieve/pii/S0927776505002730 - Similar
so what are Literature values referred to in the last ref?
Anyway, this is all the help I can provide, good luck!
|  liz askew
United Kingdom
Works in field
Native speaker of:  English
PRO pts in category: 8
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