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  3. Medical: Pharmaceuticals

reliance

German translation: Abhängigkeit

GLOSSARY ENTRY (DERIVED FROM QUESTION BELOW)
English term or phrase:reliance
German translation:Abhängigkeit
Entered by: Dr. Georg Schweigart

11:09 Apr 9, 2012
English to German translations [PRO]
Medical - Medical: Pharmaceuticals / Genetik
English term or phrase: reliance
### Beginn Original-Text ###

Mut+ EGFR is known to possess certain features.

Coupling
It couples with the HER3 receptor.

Binding
There is continuous binding of ATP and a consequent activation of the PI3K-AKT and MAPK pathways.

Hyperactivation
The PI3K-AKT pathway is substantially activated, resulting in increased survival of tumour cells.

***Reliance***
Tumour cells become reliant on the PI3K-AKT pathway for survival.
This reliance of a tumour cell on a single pathway or receptor is known as 'oncogene addiction'.

### Ende Original-Text ###

Mut+ = mutationspositiv
EGFR = epidermal growth factor receptor > epidermaler Wachstumsfaktor-Rezeptor
HER3 = human epidermal growth factor receptor 3

Die Übersetzung sollte nicht nur dem Sinne nach sein, sondern es muss genau das Fachwort sein, das in deutschen Fachtexten verwendet wird.
Dr. Georg Schweigart
Germany
Local time: 12:06
Abhängigkeit
Explanation:

...die Tumorzellen sind von diesem Pfad abhängig (Onkogen-Abhängigkeit),
siehe z. B. hier:

"...Beim malignen Melanom spielt die Aktivierung sowohl des RAF-MEK-ERK (MAPK) als auch des PI3K-AKT-mTOR (PI3K) Signaltransduktionsweges eine entscheidende Rolle bei der Tumorprogression und Therapieresistenz..."

http://www.melanomverbund.de/index.php?id=829
Selected response from:

Harald Moelzer (medical-translator)
Germany
Local time: 12:06
Grading comment
Vielen Dank!
4 KudoZ points were awarded for this answer



Summary of answers provided
4 +5Abhängigkeit
Harald Moelzer (medical-translator)


  

Answers


8 mins   confidence: Answerer confidence 4/5Answerer confidence 4/5 peer agreement (net): +5
Abhängigkeit


Explanation:

...die Tumorzellen sind von diesem Pfad abhängig (Onkogen-Abhängigkeit),
siehe z. B. hier:

"...Beim malignen Melanom spielt die Aktivierung sowohl des RAF-MEK-ERK (MAPK) als auch des PI3K-AKT-mTOR (PI3K) Signaltransduktionsweges eine entscheidende Rolle bei der Tumorprogression und Therapieresistenz..."

http://www.melanomverbund.de/index.php?id=829

Harald Moelzer (medical-translator)
Germany
Local time: 12:06
Specializes in field
Native speaker of: Native in GermanGerman
PRO pts in category: 676
Grading comment
Vielen Dank!

Peer comments on this answer (and responses from the answerer)
agree  Sven Petersson: http://darwin.bth.rwth-aachen.de/opus3/volltexte/2007/1590/p...
22 mins
  -> Many thanks, Sven!!
agree  Reinhard Wenzel
3 hrs
  -> Dankeschön!!
agree  uyuni
19 hrs
  -> Dankeschön!!
agree  Dr. Matthias Schauen: Genau. Meines Wissens ist weder "reliance" noch "Abhängigkeit" hier ein spezielles Fachwort.
23 hrs
  -> Dankeschön!!
agree  Ramey Rieger (X): JA!
1 day 8 hrs
  -> Thanks again :-)
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