KudoZ home » English » Medical: Pharmaceuticals

fixed and free combination

English translation: fixed vs. free combination

Advertisement

Login or register (free and only takes a few minutes) to participate in this question.

You will also have access to many other tools and opportunities designed for those who have language-related jobs
(or are passionate about them). Participation is free and the site has a strict confidentiality policy.
19:48 May 16, 2005
English to English translations [PRO]
Medical - Medical: Pharmaceuticals
English term or phrase: fixed and free combination
What do free and fixed mean in this context (provided below)?
1. Does “fixed combination” mean “combination medicament (two compounds in a single dosage form)”?
2. Does “free combination” mean “combination of separate/different dosage forms”?

3. Medicament suited for the combined use according to claim 1 or 2, which comprises roflumilast and R, R-formoterol in fixed or free combination.
4. Medicament according to claim 3, which is a fixed oral combination.
5. Medicament according to claim 3, which is a fixed oral combination containing roflumilast in a daily dosage of from 100 to 500 pg and R, R-formoterol in a daily dosage of from 10 to 120 pg.
6. Medicament according to claim 3, which is a free combination comprising roflumilast in an oral formulation and R, R-formoterol in a formulation suited for administration by inhalation.
7. Medicament according to claim 3, which is a free combination comprising. roflumilast in an oral formulation in a daily dosage of from 100 to 500 ug and R, R-formoterol in a formulation suited for administration by inhalation in a daily dosage of from 10 to 50 ug.

More context:

Synergistic Combination Comprising Roflumilast and (R, R)-Formoterol

The combination therapy which is the subject matter of this invention comprises administering roflumilast with R, R-formoterol to prevent onset of a pulmonary disease event or to treat an existing condition. The two compounds may be administered together in a single dosage form. Or they may be administered in different dosage forms. They may be administered at the same time. Or they may be administered both close in time or remotely, such as where one drug is administered in the morning and the second drug is administered in the evening.

"Combined use" or "combination" within the meaning of the present invention is to be understood as meaning that the individual components can be administered simultaneously (in the form of a combination medicament), more or less simultaneously (from separate pack units) or in succession (directly in succession or else alternatively at a relatively large time interval) in a manner which is known per se and customary. As an example, one drug could be taken in the morning and one later in the day. Or in another scenario, one drug could be taken twice daily and the other once daily, either at the same time as one of the twice-a-day dosing occurred, or separately.
Barbara Piela
Local time: 10:24
English translation:fixed vs. free combination
Explanation:
A fixed combination drug contains two (or more) different drugs in one tablet (or other form) - so the patient always takes that combination of drugs in predetermined proportions.

Free combination involves taking the different drugs in separate tablets or medicines - so the proportions can, if required, be varied.


fixed-combination drug
drug containing fixed amounts of two or more ingredients
http://www.english-dictionary.us/meaning/fixed-combination_d...
Selected response from:

Armorel Young
Local time: 09:24
Grading comment
Thank you!
4 KudoZ points were awarded for this answer

Advertisement


Summary of answers provided
3 +5fixed vs. free combination
Armorel Young


  

Answers


34 mins   confidence: Answerer confidence 3/5Answerer confidence 3/5 peer agreement (net): +5
fixed vs. free combination


Explanation:
A fixed combination drug contains two (or more) different drugs in one tablet (or other form) - so the patient always takes that combination of drugs in predetermined proportions.

Free combination involves taking the different drugs in separate tablets or medicines - so the proportions can, if required, be varied.


fixed-combination drug
drug containing fixed amounts of two or more ingredients
http://www.english-dictionary.us/meaning/fixed-combination_d...

Armorel Young
Local time: 09:24
Native speaker of: Native in EnglishEnglish
PRO pts in category: 4
Grading comment
Thank you!

Peer comments on this answer (and responses from the answerer)
agree  Jianming Sun
5 hrs

agree  Alaa AHMED
10 hrs

agree  Elizabeth Rudin
11 hrs

agree  xxxAlfa Trans
2 days18 hrs

agree  Michal Szczygiel
3559 days
Login to enter a peer comment (or grade)




Return to KudoZ list


KudoZ™ translation help
The KudoZ network provides a framework for translators and others to assist each other with translations or explanations of terms and short phrases.



See also:



Term search
  • All of ProZ.com
  • Term search
  • Jobs
  • Forums
  • Multiple search