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three-arm study and randomized

English translation: three groups of patients; which patients are assigned to each group is decided by chance

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GLOSSARY ENTRY (DERIVED FROM QUESTION BELOW)
English term or phrase:three-arm study and randomized
English translation:three groups of patients; which patients are assigned to each group is decided by chance
Entered by: xxxElena Sgarbo
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01:55 Feb 23, 2006
English to English translations [PRO]
Medical - Medical (general)
English term or phrase: three-arm study and randomized
A double-blind, randomised, multi-center, three-arm study to assess the safety and efficacy of xxxcin administered intramuscularly at three different dosing regimens

What does randomised and three-arm study mean in this text?
xxxSanjiv Sadan
Local time: 12:24
three groups of patients; which patients are assigned to each group is decided by chance
Explanation:
Hi Sanjiv,

The study attempts to analyze 3 different doses of an injectable drug, apparently. This is why the inbestigators need 3 groups of patients, called "arms" (i.e., "A, B, & C"). Pts in each arm will receive one of the 3 doses under study.

To prevent any selection biases in the arms, which patient is assigned to each arm is decided by chance. That means that if a pt. is deemed eligible for the study, a coin toss (or a similar procedure, rather) will decide whether the pt. is randomized to arm A, B, or C.

HTH,

Elena

--------------------------------------------------
Note added at 10 mins (2006-02-23 02:06:01 GMT)
--------------------------------------------------

:::::: Not "inbestigators", but inVestigators, of course!
Selected response from:

xxxElena Sgarbo
Grading comment
Thanks to both of you for your great explanations which have make the things crystal clear.
4 KudoZ points were awarded for this answer

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Summary of answers provided
5 +9three groups of patients; which patients are assigned to each group is decided by chancexxxElena Sgarbo


Discussion entries: 4





  

Answers


9 mins   confidence: Answerer confidence 5/5 peer agreement (net): +9
three groups of patients; which patients are assigned to each group is decided by chance


Explanation:
Hi Sanjiv,

The study attempts to analyze 3 different doses of an injectable drug, apparently. This is why the inbestigators need 3 groups of patients, called "arms" (i.e., "A, B, & C"). Pts in each arm will receive one of the 3 doses under study.

To prevent any selection biases in the arms, which patient is assigned to each arm is decided by chance. That means that if a pt. is deemed eligible for the study, a coin toss (or a similar procedure, rather) will decide whether the pt. is randomized to arm A, B, or C.

HTH,

Elena

--------------------------------------------------
Note added at 10 mins (2006-02-23 02:06:01 GMT)
--------------------------------------------------

:::::: Not "inbestigators", but inVestigators, of course!

xxxElena Sgarbo
Specializes in field
Native speaker of: Native in SpanishSpanish
PRO pts in category: 87
Grading comment
Thanks to both of you for your great explanations which have make the things crystal clear.

Peer comments on this answer (and responses from the answerer)
agree  NancyLynn: I guess I'm typing slowly tonight! at least we're in agreement for the asker ;-)
3 mins

agree  Marina Soldati
4 mins

agree  Elena Petelos: :-)
4 mins

agree  Ioana Costache
13 mins

agree  Bjørn Anthun: http://www.clinicaltrials.gov/ct/info/glossary - multicenter study: a clinical trial that is carried out at more than one medical institution
2 hrs

agree  xxxMurielP
5 hrs

agree  Ford Prefect
6 hrs

agree  xxxAlfa Trans
1 day9 hrs

agree  Jörgen Slet
2 days21 hrs
Login to enter a peer comment (or grade)




Voters for reclassification
as
PRO / non-PRO
PRO (3): xxx@caduceus, Veronica Prpic Uhing, Ford Prefect


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Changes made by editors
Feb 23, 2006 - Changes made by Ford Prefect:
LevelNon-PRO » PRO


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