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13:57 Feb 9, 2010
English to Arabic translations [PRO] Science - Biology (-tech,-chem,micro-) Additional field(s): Medical (general), Genetics
English term or phrase:gene silencing
Definition from MedicineNet, Inc.: Gene silencing: A mechanism by which cells shut down large sections of chromosomal DNA. Gene silencing is done by incorporating the DNA to be silenced into a form of DNA called heterochromatin that is already silent.
The process of gene silencing is important for the differentiation of many different types of cells.
Example sentence(s):
Evidence is emerging that geminiviruses and plant pararetroviruses can interact with the gene silencing system either from introduced DNA constructs or during viral pathogenesis. Some observations suggest there are complex relationships between DNA viral activity, transcriptional and post-transcriptional gene silencing mechanisms. biotech-info.net
The biggest challenges in the field at the moment are understanding two things: how does DNA methylation participate in gene silencing (and that includes what molecules target the DNA methylation to these promoter regions), and why is the cancer cell doing this? The Thomson Corporation
In 2005, Pikaard and his collaborators published research showing that the major function of Pol IV is to generate siRNAs, thereby singling out this RNA polymerase as a potential player in gene silencing. ScienceDaily LLC
Definition: عبارة عن عملية تقوم الخلايا من خلالها بإغلاق أو تعطيل (تصميت) قطاعات كبيرة من الحامض النووي للكروموسومات. بالإضافة إلى أهمية هذه العملية في تنوع الخلايا التي يتم تصنيعها فإنها أيضاً تعتبر حصناً مناعياً ضد الفيروسات وغيرها من العناصر النووية الضارة.
Definition from own experience or research: عبارة عن عملية تقوم الخلايا من خلالها بإغلاق أو تعطيل (تصميت) قطاعات كبيرة من الحامض النووي للكروموسومات. بالإضافة إلى أهمية هذه العملية في تنوع الخلايا التي يتم تصنيعها فإنها أيضاً تعتبر حصناً مناعياً ضد الفيروسات وغيرها من العناصر النووية الضارة.
Example sentence(s):
علاج الأمراض الوراثية بتعطيل الجينات المسببة لها - Graaam forum
Explanation: Some like to call it الصمت الجيني which would translate into genetic silence. This translation is clearly wrong as the point in discussion here is not silence but silencing. I also prefer the expression "التصميت الجيني" and not الإصمات which could be mistaken for other meanings in Arabic.
Fahd Hassanein Egypt Local time: 11:45 Native speaker of: Arabic PRO pts in category: 17
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peer agreement (net): +3
