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Medical - Medical: Pharmaceuticals
Additional field(s): Medical: Cardiology, Medical (general) | | English term or phrase: bioavailability | Definition from USC Kidney Transplant Program :
a measure of how much of an administered drug is absorbed into the bloodstream, actually reaching the intended site of action in the body. For example, medicine is absorbed from the GI tract, travels through the bloodstream, and reaches the organ tissues, where it works to fight infection, prevent rejection, etc.
Example sentence(s): - Differences in bioavailability among formulations of a given drug can have clinical significance; thus, knowing whether drug formulations are equivalent is essential. Merck & Co., Inc.
- The term “relative bioavailability” refers to a comparison of two or more dosage forms in terms of their relative rate and extent of absorption. If an intravenous injection is employed as the reference dose, one can determine the absolute bioavailability of the test dosage form. Informa plc
- Drug candidates can be tested for their desired therapeutic activity, but it is not yet possible to predict whether or not a compound will have sufficient bioavailability to be useful and practical. US National Institutes of Health
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| التوافر الحيوي | Definition:
هو النسبة التي وصلها الدواء فعليًا في بلازما الدم إلى الجرعة الفعلية التي أعطيت لها الشخص ، وعادة ما يعتبر التوافر الحيوي للجرعة التي تعطى عن طريق الوريد بنسبة 1:1. أما الجرعات التي تعطى عن طريق العضل فتعطى نسبًا أقل من 1 (لأن اعتبارها 1 يعبر عن نسبة مثالية من الصعب الحصول عليها) لكن هنالك حالات لا تحدث فيها هذه النسبة بسبب التقويض الذي يحصل أغلبه في الكبد أو في أعضاء الجسم الأخرى.
أما عن طريق الفم فالنسب تتفاوت وحسب نوع الدواء وتمثله وتقويضه في الجسم، لذلك كثيرًا ما تقارن الجرع بين جرعها وتوافرها الحيوي عن طريق الوريد (إن وجد - بسبب عدم إمكانية استخدام هذا الطريق لكل الأدوية) وعن طريق الفم. |
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Dr. Ola
Egypt
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