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bound activating Fc-gamma receptors

Chinese translation: 与具有活化作用的Fc-γ受体结合

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GLOSSARY ENTRY (DERIVED FROM QUESTION BELOW)

English term or phrase:	bound activating Fc-gamma receptors
Chinese translation:	与具有活化作用的Fc-γ受体结合
Entered by:	ration

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04:14 Oct 13, 2007

English to Chinese translations [PRO]
Medical - Biology (-tech,-chem,micro-) / biotech

English term or phrase: bound activating Fc-gamma receptors

CRP(C-reactive protein) enhanced secretion of IL-6; {bound activating Fc-gamma receptors}; activated the PI3K/Akt, ERK, and NF-kB pathways; and inhibited caspase cascade activation induced by chemotherapy drugs. Furthermore, CRP was shown to synergize with IL-6 in protecting myeloma cells from apoptosis.

ration KudoZ activity Questions: 17 (none open) Answers: 182
Local time: 06:56

与活化的Fc-γ受体结合

Explanation:

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Note added at 32 mins (2007-10-13 04:47:18 GMT)
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Fcγ受体有3类：FcγRI (CD64，一种高亲和性受体)、 Fcγ RII和 RIII (又分别称为CD32 和CD16，都属于低亲和性受体)。

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Note added at 39 mins (2007-10-13 04:54:24 GMT)
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Fc受体（Fc receptors，FcR）是结合免疫球蛋白（Ig）Fc段的表面分子，可识别抗体决定簇。

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Note added at 4 hrs (2007-10-13 08:21:01 GMT)
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你的理解是正确的，我又查了一点资料：
Ｆｃ受体γ链是Ｆｃ受体(包括ＦｃαＲ、ＦｃεＲ、ＦｃγＲⅠ、ＦｃγＲⅡＡ、ＦｃγＲⅢＡ)的一个组成亚单位,γ链以同源二聚体的形式组成Ｆｃ受体的跨膜段和胞内段。Ｆｃ受体γ链的存在增强Ｆｃ受体与免疫球蛋白的亲和力。在免疫应答过程中,Ｆｃ受体与免疫复合物结合后,通过γ链中的免疫受体酪氨酸的活化基因序列向细胞内传递活化信号。
http://www.labweb.cn/articleview/2006-10-14/article_view_359...

因此应该是具有活化作用的Fc-γ受体

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Note added at 4 hrs (2007-10-13 08:23:10 GMT)
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activating有“活化”和“具有活化作用”两层意思，但具体是哪一个解释应该从受体的结构和作用来看，这就需要查相关的资料了。

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