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Reports indicate that cryopreserved aortic valve allografts have a better long-term survivability than other bioprostheses, such as the porcine xenograft. Unlike xenografts, allograft valves do not require treatment with glutaraldehyde and may therefore retain much of their original mechanical function. American Assoc. for Thoracic Surgerry
Persistent expression of human genes by the xenografts at higher passages was assessed by RT-PCR amplification of the human β–globin gene. This xenograft model was used in the preclinical evaluation of an adenoviral vector containing a β-galactosidase reporter gene and a wild-type p53 gene. ScienceDirect
A transparent window chamber allowed noninvasive microscopic observation of human tumor xenograft tissue in athymic nude mice. The xenografts were derived from the LS174T colon carcinoma cell line shown to express CEA in vitro (18) and in vivo (19–21). The National Academy of Sciences
Definition from 百度: 异种移植指将一个物种的组织移植到另一个物种体内，例如，从猪到人。和同种移植不同的是，异种之间存在很大差异，从而使得这种移植成功的可能性很小。负责组织排斥的免役系统将很容易地识别出外来组织并强烈排斥它。既然动物可以为移植提供无尽的来源，异种移植一直是人们梦寐以求的事。猪虽然看上去和人有着很大的差异，却有着相似的器官结构，因而成为该领域内研究的焦点；猴子是另一类有吸引力的种群。 理论上讲选择与人亲缘关系最近的其它灵长类动物作为移植物来源乃最佳方案，然而灵长目动物数量稀少，饲养与繁殖不易，价格昂贵，脏器（与成年人相比）体积偏小，存在逆转录病毒感染的危险，可能会引发伦理学争论等等一般不考虑作为异种移植物来源的候选者。
Adsion Canada Local time: 08:09 Native speaker of: Chinese PRO pts in category: 48
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