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microprecipitated bulk powder


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17:23 Nov 29, 2010
This question was closed without grading. Reason: Answer found elsewhere

English to Danish translations [PRO]
Medical - Medical: Pharmaceuticals
English term or phrase: microprecipitated bulk powder
Context from a clinical trial protocol:

20 patients received doses of [drug] ranging from 160 mg to 1120 mg b.i.d using the optimized drug formulation (referred to as microprecipitated bulk powder [MBP] formulation) with greater bioavailability
Annette Skipper
Denmark
Local time: 15:49

Summary of reference entries provided
PLX4032 BRAF eller RAF hæmmer
andres-larsen

Discussion entries: 2





  

Reference comments


1 day5 hrs
Reference: PLX4032 BRAF eller RAF hæmmer

Reference information:
Landvindinger i kræftforskningen 2010 - Kræftens Bekæmpelse
8. sep 2010 ... En ny type behandling (PLX4032), der virker ved at hæmme et gen ved ... Rigshospitalet kører i øjeblikket et forsøg med en BRAF-hæmmer til ...
www.cancer.dk/Hjaelp+viden/fakta+... -

Landvindinger i kræftforskningen 2010 - Kræftens Bekæmpelse
BRAF-hæmmer kan få modermærkekræft til at skrumpe ... En ny type ...
www.cancer.dk/Hjaelp+viden/fakta+... -

Dagens Medicin: Genterapi viser effekt på hudkræftpatienter
3. sep 2010 ... Det nye præparat PLX4032 er baseret på viden om, at ca. halvdelen af de ... der får hudkræft, har en bestemt mutation i et gen kaldet BRAF. ...
www.dagensmedicin.dk/nyheder/2010/09/... -

Clinical efficacy of a RAF inhibitor needs broad target blockade ...
30 Sep 2010 ... The initial crystalline formulation yielded modest drug exposures, so PLX4032 was reformulated as a micro-precipitated bulk powder (MBP), and doses ranging from 160 to 1120 ... This improved bioavailability was also observed in patients, ... Dose-limiting toxicities detected at the 1120 mg BID dose ...
www.nature.com/nature/journal/vnfv/nc... -

Inhibition of Mutated, Activated BRAF in Metastatic Melanoma
8 Sep 2010 ... itated-bulk-powder formulation at a dose of 160 mg. (two 80-mg capsules) twice daily, ...... was reformulated as a micro-precipitated bulk powder (MBP), and doses ranging from 160 to 1120mg BID were sequentially evaluated. ... drug bioavailability, an approximately tenfold improvement. This ...
cancer.ucsf.edu/_docs/intranet/journa... -

andres-larsen
Venezuela
Specializes in field
Native speaker of: Native in EnglishEnglish
PRO pts in category: 14
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