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adjudicated.

Dutch translation: beoordelen/evalueren

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GLOSSARY ENTRY (DERIVED FROM QUESTION BELOW)

English term or phrase:	adjudicated.
Dutch translation:	beoordelen/evalueren

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14:13 Jan 3, 2012

The asker opted for community grading. The question was closed on 2012-01-06 21:54:09 based on peer agreement (or, if there were too few peer comments, asker preference.)

English to Dutch translations [PRO]
Medical - Medical (general) / study protocol

English term or phrase: adjudicated.

Major bleeding events, stroke, TIA and systemic embolism will be adjudicated.

Hermine M. Slootweg-Zaatman KudoZ activity Questions: 24 (none open) (4 without valid answers) Answers: 15
Local time: 15:55

beoordelen/evalueren

Explanation:
*

Selected response from:

Katrien De Clercq
Local time: 15:55

Grading comment

Selected automatically based on peer agreement.
4 KudoZ points were awarded for this answer

Summary of answers provided

4 +2

beoordelen/evalueren

Katrien De Clercq

3 +1

(worden) beoordeeld op geldigheid

Barend van Zadelhoff

Discussion entries: 2

Answers

12 mins confidence:

peer agreement (net): +2

beoordelen/evalueren

Explanation:
*

Katrien De Clercq
Local time: 15:55
Specializes in field
Native speaker of:

Dutch,

Flemish
PRO pts in category: 35

Grading comment

Selected automatically based on peer agreement.

45 mins confidence:

peer agreement (net): +1

(worden) beoordeeld op geldigheid

Explanation:
zou mijn conclusie zijn

Of: (worden) beoordeeld op frequentie van voorkomen

in de zin van of deze gebeurtenissen voldoen aan de definitie
en of ze meegenomen moeten worden bij de beoordeling van de resultaten van het onderzoek of niet
ze worden wel of niet 'toegewezen' om tot een objectieve beoordeling van de resultaten van het onderzoek te komen

Methods We reviewed the literature concerning central adjudication and documented the experience of adjudication in several clinical trials. Since definitions for nonfatal events are generally heterogeneous and subjective, one reason for a central process of adjudication is to assist in assuring systematic application of the definition used in the trial.

http://ctj.sagepub.com/content/5/1/56.abstract

Clinical events committees (CEC) are used routinely to adjudicate suspected end-points in cardiovascular trials, but little information has been published about the various processes used. We reviewed results of the CEC process used to identify and adjudicate suspected end-point (post-enrolment) myocardial infarction (MI) in the large Platelet Glycoprotein IIb/IIIa in Unstable Angina: Receptor Suppression Using Integrilin (Eptifibatide) Therapy (PURSUIT) trial.

The PURSUIT trial randomised 10,948 patients with acute coronary syndromes to receive eptifibatide or placebo. A central adjudication process was established prospectively to identify all suspected MIs and adjudicate events based on protocol definitions of MI. Suspected MIs were identified by systematic review of data collection forms, cardiac enzyme results, and electrocardiograms. Two physicians independently reviewed all suspected events. If they disagreed whether a MI had occurred, a committee of cardiologists adjudicated the case.Results
The CEC identified 5005 patients with suspected infarction (46%), of which 1415 (28%) were adjudicated as end-point infarctions. As expected, the process identified more end-point events than did the site investigators. Absolute and relative treatment effects of eptifibatide were smaller when using CEC-determined MI rates rather than site investigator-determined rates. The site-investigator reporting of MI and the CEC assessment of MI disagreed in 20% of the cases reviewed by the CEC.Conclusions
End-point adjudication by a CEC is important, to provide standardised, systematic, independent, and unbiased assessment of end-points, particularly in trials that span geographic regions and clinical practice settings. Understanding the CEC process used is important in the interpretation of trial results and event rates.

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC57749/

Barend van Zadelhoff
Netherlands
Local time: 15:55
Specializes in field
Native speaker of:

Dutch
PRO pts in category: 109

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adjudicated.

Dutch translation: beoordelen/evalueren

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adjudicated.

Dutch translation: beoordelen/evalueren

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KudoZ™ translation helpThe KudoZ network provides a framework for translators and others to assist each other with translations or explanations of terms and short phrases.

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