fraught

French translation: lourds de conséquences (ici)

GLOSSARY ENTRY (DERIVED FROM QUESTION BELOW)

English term or phrase:	fraught
French translation:	lourds de conséquences (ici)
Entered by:	PFB (X)

13:49 Aug 13, 2006

English to French translations [PRO]
Medical - Medical: Pharmaceuticals / AIDS trials

English term or phrase: fraught

I've always seen "fraught" followed by something - fraught with meaning, etc. However in this text it is the final word in the sentence, and I'm not sure how to render the meaning.

So we had the FDA Treatment IND regulations, which specify how promising new agents not yet approved or licensed for sale can be made available, under protocol, to patients with life-threatening illnesses. But it’s important to remember that these changes, and particularly changes in the way clinical trials are designed—shortened timelines, substitution of biomarkers for clinical outcomes—may be fraught. Twenty-four weeks of safety and efficacy data required for accelerated approval can mean that toxicities will only emerge after approval, as the agent is administered longer term in real-world clinical settings.

NancyLynn KudoZ activity Questions: 1260 (9 open) (6 without valid answers) (15 closed without grading) Answers: 2221 Canada
Local time: 11:50

lourds de conséquences

Explanation:
Les changements.... sont lourds de conséquences. Peut-être?

D'après ce que je comprends, les changement apportés à la façon dont les essais sont conduits rendent ces derniers moins probants: un raccourcissement des délais peut ne faire apparaître la toxicité qu'après la fin de l'essai (d'après le texte).

Juste une suggestion sur une base "linguistique", car ce n'est pas du tout mon domaine.

Selected response from:

PFB (X)
Local time: 17:50

Grading comment

merci beaucoup Philippe !
4 KudoZ points were awarded for this answer

Summary of answers provided

4 +1

(peuvent) provoquer beaucoup de tensions

CMJ_Trans (X)

3 +1

lourds de conséquences

PFB (X)

comporte plusieurs enjeux, tant au niveau....

Debbie Tacium Ladry

Answers

21 mins confidence:

peer agreement (net): +1

(peuvent) provoquer beaucoup de tensions

Explanation:
on trouve ce type d'utilisation assez souvent dans le langage parlé

ne se passent pas toujours comme une lettre à la poste

CMJ_Trans (X)
Local time: 17:50
Native speaker of:

English
PRO pts in category: 31

36 mins confidence:

peer agreement (net): +1

lourds de conséquences

PFB (X)
Local time: 17:50
Native speaker of: French
PRO pts in category: 12

Grading comment

merci beaucoup Philippe !

40 mins confidence:

comporte plusieurs enjeux, tant au niveau....

Explanation:
a suggestion - I'm not sure if there's a bit of interpreting required. But I agree with CMJ that there should be a sense of emotional distress or tension.

Debbie Tacium Ladry
Local time: 11:50
Specializes in field
Native speaker of: English
PRO pts in category: 20

Login or register (free and only takes a few minutes) to participate in this question.

You will also have access to many other tools and opportunities designed for those who have language-related jobs (or are passionate about them). Participation is free and the site has a strict confidentiality policy.

Return to KudoZ list

KudoZ™ translation help

The KudoZ network provides a framework for translators and others to assist each other with translations or explanations of terms and short phrases.

See also:

ProZ.com term search

Search millions of term translations

fraught

French translation: lourds de conséquences (ici)

Answers

KudoZ™ translation help

Your current localization setting

Select a language

fraught

French translation: lourds de conséquences (ici)

Answers

KudoZ™ translation help

You have native languages that can be verified

Your current localization setting

Select a language