also relatively less sensitive disease

French translation: see explanation of English

12:51 Oct 27, 2007

English to French translations [PRO]
Medical - Medical: Pharmaceuticals / genetics

English term or phrase: also relatively less sensitive disease

Deux produits sont actifs dans la LMC : nilotinib et imatinib. Le nilotinib a la même efficacité que les patients LMC, au préalable, se soient montrés ou non résistants/intolérants à l'imatinib.
Ci-après le texte qui donne la logique de cette similiraté des résultats, mais que je ne comprends pas :
"The estimated percent of patients who achieved a major cytogenetic response and who did not discontinue nilotinib due to progression or death for at least 6 months after achievement of response was 96% (Figure 2). Similar rates of major cytogenetic response were observed in resistant- and intolerant- patients. This is likely due to the rigorous definition of imatinib intolerance, which excluded imatinib-intolerant patients who had achieved a prior major cytogenetic response (thus the imatinib-intolerant patients had -also relatively less sensitive disease-)."

François Begon KudoZ activity Questions: 19 (none open) (2 closed without grading) Answers: 2375 France
Local time: 16:19

French translation:see explanation of English

Explanation:
Imatinib intolerance was defined in such a way that patients who had achieved a major cytogenetic response previously could not be classified as imatinib-intolerant. The effect is that, by definition, the imatinib-intolerant patients all had pathologies that were probably less likely to respond to treatment (with nilotinib), since those with sensitive disease - "good responders" - were excluded.

>> the potential for response was similar in both imatinib-intolerant and imatinib-resistant groups.

It's all very logical :-)

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Note added at 3 hrs (2007-10-27 16:45:48 GMT)
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Donc, comme les patients *résistants* à l'imatinib, les patients définis *intolérants* à l'imatinib avaient démontré une réponse moins que maximale au traitement antérieur à l'imatinib.

Selected response from:

Dr Sue Levy (X)
Local time: 16:19

Grading comment

Merci bcp
4 KudoZ points were awarded for this answer

Summary of answers provided

4 +2

see explanation of English

Dr Sue Levy (X)

3 +1

pathologie moins sensible ou à sensibilité réduite au traitement

Drmanu49

Answers

24 mins confidence:

peer agreement (net): +1

-also relatively less sensitive disease- pathologie moins sensible ou à sensibilité réduite au traitement

Explanation:
Possibilité, ces patients intolérants à la molécule présentaient une pathologie moins sensible ou de sensibilité réduite au traitement.

Drmanu49
France
Local time: 16:19
Specializes in field
Native speaker of:

English,

French
PRO pts in category: 1923

1 hr confidence:

peer agreement (net): +2

-also relatively less sensitive disease-

see explanation of English

Dr Sue Levy (X)
Local time: 16:19
Specializes in field
Native speaker of:

English
PRO pts in category: 108

Grading comment

Merci bcp

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