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estimated mean ratios

German translation: geschätzte Mittelwerte der Verhältnisse

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22:28 Jul 20, 2011

English to German translations [PRO]
Medical - Mathematics & Statistics / SmPC

English term or phrase: estimated mean ratios

Ausgangstext:
There was an increase in plasma ultrafiltrate (PUF) platinum AUC, AUC/dose and a decrease in total and renal CL and Vss with increasing renal impairment especially in the (small) group of patients with severe renal impairment: point estimate (90% CI) of **estimated mean ratios** by renal status versus normal renal function for AUC/dose were 1.36 (1.08, 1.71), 2.34 (1.82, 3.01) and 4.81 (3.49, 6.64) for patients with mild and moderate and in severe renal failure respectively.

Vielen Dank für die Hilfe!

xxx@caduceus KudoZ activity Questions: 180 (none open) (5 closed without grading) Answers: 694 United States
Local time: 22:46

German translation:geschätzte Mittelwerte der Verhältnisse

Explanation:
oder: geschätzte Verhältnis-Mittelwerte

Vgl. "... point estimate (90% CI) of estimated mean *ratios* by renal status versus normal renal function ***for AUC/dose*** were ...

=> "estimated mean ratios" bezieht sich auf "AUC/dose", also auf *Verhältnis*werte.

Dies macht Sinn, weil pharmakokinetische Parameter, z. B. die Platin-Clearance im Plasma, dosisabhängig sind oder sein können. Das Verhältnis AUC/Dosis steht allgemein mit der Gesamt-Clearance C,tot, wie folgt in Beziehung

AUC / Dosis = 1 / C,tot

Ref.
Pharmakologie und Toxikologie: Arzneimittelwirkungen verstehen- Medikamente ...
Von Heinz Lüllmann,Klaus Mohr,Lutz Hein
Gl. 6

Selected response from:

sci-trans
Local time: 06:46

Grading comment

Danke!
3 KudoZ points were awarded for this answer

Summary of answers provided

geschätzt geometrische Mittel der Verhältnisse

DLyons

geschätzte Mittelwerte der Verhältnisse

sci-trans

geschätzte Mittelwerte

DERDOKTOR

Discussion entries: 1

Answers

7 hrs confidence:

geschätzte Mittelwerte

Explanation:
würde ich sagen.

DERDOKTOR
Local time: 06:46
Native speaker of:

German
PRO pts in category: 4

10 hrs confidence:

geschätzte Mittelwerte der Verhältnisse

sci-trans
Local time: 06:46
Native speaker of: German
PRO pts in category: 38

Grading comment

Danke!

19 hrs confidence:

geschätzt geometrische Mittel der Verhältnisse

Explanation:
1.36 = SQRT(1.08*1.71)
2.34 = SQRT(1.82*3.01)
4.81 = SQRT(3.49*6.64)

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Note added at 1 day10 hrs (2011-07-22 09:12:03 GMT)
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The mean ratio was estimated in the standard way by taking the geometric mean of the ratio estimates from the data (here apparently only two estimates were made for each treatment)

DLyons
Ireland
Local time: 05:46
Specializes in field
Native speaker of:

English

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estimated mean ratios

German translation: geschätzte Mittelwerte der Verhältnisse

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estimated mean ratios

German translation: geschätzte Mittelwerte der Verhältnisse

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