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Chinese hamster ovary forward gene mutation assay

German translation: Assay auf Vorwärtsmutation in CHO-Zellen

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GLOSSARY ENTRY (DERIVED FROM QUESTION BELOW)
English term or phrase:Chinese hamster ovary forward gene mutation assay
German translation:Assay auf Vorwärtsmutation in CHO-Zellen
Entered by: Gert Sass (M.A.)
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17:45 Mar 7, 2007
English to German translations [PRO]
Medical - Medical: Pharmaceuticals / alprostadil product characteristics
English term or phrase: Chinese hamster ovary forward gene mutation assay
Preclinical safety data
Carcinogenicity, Mutagenesis, Impairment of Fertility

Long-term carcinogenicity studies of alprostadil have not been conducted. Alprostadil showed no evidence of mutagenicity in vitro in the Ames bacterial reverse mutation test, the unscheduled DNA synthesis assay in rat hepatocytes, or the ***Chinese hamster ovary forward gene mutation assay***, and unscheduled DNA synthesis (UDS), nor was there evidence of mutagenicity in vivo in the mouse micronucleus assay, or rat micronucleus, sister chromatid exchange.
Gert Sass (M.A.)
Germany
Local time: 16:28
Assay auf Vorwärtsmutation in CHO-Zellen
Explanation:
Für Assay kann man auch Test oder Prüfung sagen, Assay hat sich jedoch inzwischen eingebürgert.

Bei der Vorwärtsmutation handelt es sich um eine Genmutation, das "gen" im Englischen fällt weg, da Vorwärtsmutation ein fester Begriff ist.

CHO-Zellen sind Zellen vom Ovarium des chinesischen Hamsters, also "Chinese Hamster Ovary" = CHO. Der Assay wird sicherlich an den Zellen und nicht am Ovarium selbst durchgeführt.
Selected response from:

Ingo Dierkschnieder
United Kingdom
Local time: 15:28
Grading comment
Perfekt. Danke, Ingo.
4 KudoZ points were awarded for this answer

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Summary of answers provided
3 +3Assay auf Vorwärtsmutation in CHO-Zellen
Ingo Dierkschnieder


  

Answers


13 mins   confidence: Answerer confidence 3/5Answerer confidence 3/5 peer agreement (net): +3
chinese hamster ovary forward gene mutation assay
Assay auf Vorwärtsmutation in CHO-Zellen


Explanation:
Für Assay kann man auch Test oder Prüfung sagen, Assay hat sich jedoch inzwischen eingebürgert.

Bei der Vorwärtsmutation handelt es sich um eine Genmutation, das "gen" im Englischen fällt weg, da Vorwärtsmutation ein fester Begriff ist.

CHO-Zellen sind Zellen vom Ovarium des chinesischen Hamsters, also "Chinese Hamster Ovary" = CHO. Der Assay wird sicherlich an den Zellen und nicht am Ovarium selbst durchgeführt.

Ingo Dierkschnieder
United Kingdom
Local time: 15:28
Specializes in field
Native speaker of: Native in GermanGerman
PRO pts in category: 80
Grading comment
Perfekt. Danke, Ingo.

Peer comments on this answer (and responses from the answerer)
agree  Anne Schulz
45 mins

agree  Hildegard Klein-Bodenheimer
7 hrs

agree  Sonia Heidemann
14 hrs
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