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Omiganan 1.0% gel

German translation: 1%iges Omiganan-Gel

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19:37 Jun 4, 2007
English to German translations [PRO]
Medical - Medical: Pharmaceuticals
English term or phrase: Omiganan 1.0% gel
Hallo, hier bin ich wieder mit einer Frage, die eigentlich sehr trivial sein sollte. Dennoch habe ich damit ein Problem, welches vielleicht auch an dem Sprachgebrauch der amerikanischer Verfasser eines Benutzerhandbuchs liegt.

Was ist ein "Omiganan 1.0% gel"? Eigentlich habe ich keine Probleme damit zu sagen, was ein 1%iges Agrarosegel ist (1 g Agarose in 100 ml Puffer unter der Mikrowelle aufgelöst und auf einem entsprechenden Gelschlitten ausgegossen - so etwas habe ich mal jeden Tag getan).

Nun zu meinem Problem:

Was ist "Omiganan-1,0%-Gel"?
a) 1 Teil Omiganan auf 100 Teile Gel
b) 1 Teil Gel auf 100 Teile Wasser (keine Angabe zur Omiganankonzentration)

Vielleicht kennt sich jemand besser als ich mit der Materie aus (in dem Handbuch habe ich leider keine Angaben gefunden, die mir weiterhelfen würden - z. B. Angaben in mg/ml).
marigold7
Germany
Local time: 06:38
German translation:1%iges Omiganan-Gel
Explanation:
Omiganan pentahydrochloride (MBI 226 or omiganan) is a synthetic, linear, cationic, peptide in clinical development as a 1% gel for topical infections. ...

www.migenix.com/annuals/ICAAC_2003_6.pdf


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Note added at 6 days (2007-06-10 20:53:22 GMT)
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Wo ist dein Problem?
Wenn ich 0,2 oder 0,5 g eines 1%igen Gels auftrage, trage ich gerade mal 0,002 bis 0,005 g des Wirkstoffs auf. Also rechne das mal um, das Zeug ist ja richtig billig, zumindestens im Vergleich zu "einem" Behandlungstag auf der Intensivstation bei Kathetersepsis


Clinical Study 1: A 5-day study in 12 subjects receiving 0.5 g Omiganan 1% Gel or vehicle gel applied daily to a peripheral IV catheter site. Systemic absorption was determined on Day 1, and sensitization potential was assessed after a 2-week rest period.
Clinical Study 2: A 14-day cumulative irritation comparison in 41 subjects, with pharmacokinetic analysis on Days 14 and 15. Subjects received daily applications of 0.2 g Omiganan 1% Gel, vehicle gel, a positive control, and a negative control.
Clinical Study 3: A repeated-insult patch test (contact sensitization) in 220 subjects receiving 10 applications of 0.2 g Omiganan 1% Gel, vehicle gel, and a negative control. Sensitization potential was assessed after a 10-day rest period.
Selected response from:

Siegfried Armbruster
Germany
Local time: 06:38
Grading comment
Selected automatically based on peer agreement.
4 KudoZ points were awarded for this answer



Summary of answers provided
3 +21%iges Omiganan-Gel
Siegfried Armbruster


Discussion entries: 4





  

Answers


46 mins   confidence: Answerer confidence 3/5Answerer confidence 3/5 peer agreement (net): +2
omiganan 1.0% gel
1%iges Omiganan-Gel


Explanation:
Omiganan pentahydrochloride (MBI 226 or omiganan) is a synthetic, linear, cationic, peptide in clinical development as a 1% gel for topical infections. ...

www.migenix.com/annuals/ICAAC_2003_6.pdf


--------------------------------------------------
Note added at 6 days (2007-06-10 20:53:22 GMT)
--------------------------------------------------

Wo ist dein Problem?
Wenn ich 0,2 oder 0,5 g eines 1%igen Gels auftrage, trage ich gerade mal 0,002 bis 0,005 g des Wirkstoffs auf. Also rechne das mal um, das Zeug ist ja richtig billig, zumindestens im Vergleich zu "einem" Behandlungstag auf der Intensivstation bei Kathetersepsis


Clinical Study 1: A 5-day study in 12 subjects receiving 0.5 g Omiganan 1% Gel or vehicle gel applied daily to a peripheral IV catheter site. Systemic absorption was determined on Day 1, and sensitization potential was assessed after a 2-week rest period.
Clinical Study 2: A 14-day cumulative irritation comparison in 41 subjects, with pharmacokinetic analysis on Days 14 and 15. Subjects received daily applications of 0.2 g Omiganan 1% Gel, vehicle gel, a positive control, and a negative control.
Clinical Study 3: A repeated-insult patch test (contact sensitization) in 220 subjects receiving 10 applications of 0.2 g Omiganan 1% Gel, vehicle gel, and a negative control. Sensitization potential was assessed after a 10-day rest period.


Siegfried Armbruster
Germany
Local time: 06:38
Specializes in field
Native speaker of: Native in GermanGerman
PRO pts in category: 110
Grading comment
Selected automatically based on peer agreement.

Peer comments on this answer (and responses from the answerer)
agree  MMUlr: genau.
15 hrs

agree  Sonia Heidemann
2 days1 hr
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Changes made by editors
Jun 5, 2007 - Changes made by Steffen Walter:
FieldLaw/Patents » Medical


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