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11:20 Feb 16, 2008
English to Greek translations [PRO] Medical - Medical: Pharmaceuticals / χημική ένωση
English term or phrase:alkoxycarbonyloxymethyl ester
XXXX is a dianion with poor intestinal permeability. The introduction of labile esters on the phosphonate group masks the charge and enhances the lipophilicity/membrane transport, resulting in improved bioavailability. The prodrug, XXXX disoproxil (free base), demonstrates satisfactory aqueous solubility at neutral pH, with significant solubility enhancement under acidic conditions. The solubility behavior is controlled by a single ionization site (pKa 3.75) of the adenine base. XXXX DF is an alkoxycarbonyloxymethyl ester prodrug of XXXX with high water solubility. XXXX DF tablets are an immediate release, solid, oral dosage form.