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13:36 Nov 10, 2007
English to Italian translations [PRO] Medical - Medical: Pharmaceuticals
English term or phrase:human ether-a-go-go-related gene
The reason for concern is that domperidone in higher doses could potentially induce arrhythmias in some patients. After all, it is a HERG (*human ether-a-go-go-related gene*) receptor antagonist and could potentially alter potassium levels in the myocardium, leading to arrhythmias. The original studies in cancer patients, where domperidone was used intravenously, illustrated this point.