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Villin headpiece

Italian translation: Villina Dominio proteico C-terminale / Dominio di legame per l´actina

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GLOSSARY ENTRY (DERIVED FROM QUESTION BELOW)
English term or phrase:Villin headpiece
Italian translation:Villina Dominio proteico C-terminale / Dominio di legame per l´actina
Entered by: Francesco Barbuto
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08:31 Aug 9, 2004
English to Italian translations [PRO]
Tech/Engineering - Medical (general) / Biochemistry
English term or phrase: Villin headpiece
Excerpt:

"The Villin headpiece is a very small protein consisting of about 600 atoms. However, the cell is always surrounded by water (red/white rods), which brings the atom count up to about 10,000. Every single atom interacts with the closest 100–200 neighbors; the interactions have to be calculated every single step, and then we repeat this for a half-billion steps to generate a microsecond of simulation data. "

Masny hit in Google with Villin Headpiece but could not find an italian term for it. Perhaps: Villina? And for "headpiece"
Francesco Barbuto
Local time: 13:13
Villina Dominio proteico C-terminale / Dominio di legame per l´actina
Explanation:
Look this page:
http://tesionline.corriere.it/default/tesi.asp?idt=2769
And this paragraph:

La VILLINA è un monomero di forma globulare , Actina-legante , Ca-modulata di 95 KDa che presenta in seguito a trattamento con proteasi un frammento di 90 KDa detto “ CORE” ( N-terminale) contenente due siti di legame per il Calcio e un frammento di 8.5 KDa ( C-terminale ) denominato “ HEADPIECE” che contiene il sito di legame per l’Actina. Questa proteina è ritenuta essere un marker specifico per le cellule che esprimono “ Brush Border”
La FIMBRINA è anch’essa una proteina monomerica di forma globulare , del peso di 68 KDa, legante l’Actina e Calcio –regolata .

HEADPIECE. You can translate it like "dominio proteico C-terminale" (protein domain) or, since a functional point of view, "dominio di legame per l´actina" (or both).
The term "C-terminale" locate the domain inside the protein structure

Finally, an english definition of "protein domain" (look asterisks)
http://www.genomicglossaries.com/content/protein_structure_g...
domain: An independently folded unit within a protein, often joined by a flexible segment of the polypeptide chain. [IUPAC Bioinorganic]

***A discrete portion of a protein assumed to fold independently of the rest of the protein and possessing its own function.*** [NCBI Bioinformatics]

***A region of a protein’s amino acid sequence that has evolutionary, structural, or functional significance.*** The amino acid sequence of a domain determines a protein’s 3D structure. ... The stated goal of structural genomics, as a field, involves generating a set of structures representative of most of the possible folds for specific protein domains and then solving the structures for new proteins based on known fold- structure relationships. Pharmaceutical researchers are most interested in domains because these determine the “active” or “binding” sites of molecules. [CHI Structural proteomics report]



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Note added at 1 hr 3 mins (2004-08-09 09:35:15 GMT)
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This article confirm the validity of the term \"domain\" as a synonymous of the \"headpiece\" of villin:

Villin-type headpiece domains show a wide range of F-actin-binding ... Click here to read Villin-type headpiece domains show a wide range of F-actin-binding affinities. Vardar D, Chishti AH, Frank BS ...
www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve& db=PubMed&list_uids=11977079&dopt=Abstract

You can read:

The villin-type \"headpiece\" domain is a modular motif found at the extreme C-terminus of larger \"core\" domains in over 25 cytoskeletal proteins in plants and animals. Although headpiece is classified as an F-actin-binding domain, it has been suggested that some expressed fusion-proteins containing headpiece may lack F-actin-binding in vivo.
Selected response from:

Andrés Martínez
Spain
Local time: 13:13
Grading comment
Thank you
4 KudoZ points were awarded for this answer

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Summary of answers provided
4 +1Villina Dominio proteico C-terminale / Dominio di legame per l´actina
Andrés Martínez


  

Answers


29 mins   confidence: Answerer confidence 4/5Answerer confidence 4/5 peer agreement (net): +1
villin headpiece
Villina Dominio proteico C-terminale / Dominio di legame per l´actina


Explanation:
Look this page:
http://tesionline.corriere.it/default/tesi.asp?idt=2769
And this paragraph:

La VILLINA è un monomero di forma globulare , Actina-legante , Ca-modulata di 95 KDa che presenta in seguito a trattamento con proteasi un frammento di 90 KDa detto “ CORE” ( N-terminale) contenente due siti di legame per il Calcio e un frammento di 8.5 KDa ( C-terminale ) denominato “ HEADPIECE” che contiene il sito di legame per l’Actina. Questa proteina è ritenuta essere un marker specifico per le cellule che esprimono “ Brush Border”
La FIMBRINA è anch’essa una proteina monomerica di forma globulare , del peso di 68 KDa, legante l’Actina e Calcio –regolata .

HEADPIECE. You can translate it like "dominio proteico C-terminale" (protein domain) or, since a functional point of view, "dominio di legame per l´actina" (or both).
The term "C-terminale" locate the domain inside the protein structure

Finally, an english definition of "protein domain" (look asterisks)
http://www.genomicglossaries.com/content/protein_structure_g...
domain: An independently folded unit within a protein, often joined by a flexible segment of the polypeptide chain. [IUPAC Bioinorganic]

***A discrete portion of a protein assumed to fold independently of the rest of the protein and possessing its own function.*** [NCBI Bioinformatics]

***A region of a protein’s amino acid sequence that has evolutionary, structural, or functional significance.*** The amino acid sequence of a domain determines a protein’s 3D structure. ... The stated goal of structural genomics, as a field, involves generating a set of structures representative of most of the possible folds for specific protein domains and then solving the structures for new proteins based on known fold- structure relationships. Pharmaceutical researchers are most interested in domains because these determine the “active” or “binding” sites of molecules. [CHI Structural proteomics report]



--------------------------------------------------
Note added at 1 hr 3 mins (2004-08-09 09:35:15 GMT)
--------------------------------------------------

This article confirm the validity of the term \"domain\" as a synonymous of the \"headpiece\" of villin:

Villin-type headpiece domains show a wide range of F-actin-binding ... Click here to read Villin-type headpiece domains show a wide range of F-actin-binding affinities. Vardar D, Chishti AH, Frank BS ...
www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve& db=PubMed&list_uids=11977079&dopt=Abstract

You can read:

The villin-type \"headpiece\" domain is a modular motif found at the extreme C-terminus of larger \"core\" domains in over 25 cytoskeletal proteins in plants and animals. Although headpiece is classified as an F-actin-binding domain, it has been suggested that some expressed fusion-proteins containing headpiece may lack F-actin-binding in vivo.

Andrés Martínez
Spain
Local time: 13:13
Specializes in field
Native speaker of: Spanish
PRO pts in category: 35
Grading comment
Thank you

Peer comments on this answer (and responses from the answerer)
agree  gmel117608
7 days
  -> Grazie di nuovo gmel117608
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