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bulk erosion polymer

Italian translation: polimero a dissoluzione rapida

15:45 Aug 21, 2002
English to Italian translations [PRO]
Science
English term or phrase: bulk erosion polymer
polymer compound for pharmaceutical composition
achisholm
United Kingdom
Local time: 00:39
Italian translation:polimero a dissoluzione rapida
Explanation:
è la soluzione migliore che mi è venuta in mente senza essere un'esperta di chimica e farmaceutica. Ho trovato su internet la spiegazione sotto riportata per la differenza tra bulk e surface erosion di rivestimenti polimerici di farmaci. Sui siti italiani si parla di dissoluzione, dissoluzione intrinseca e velocità di dissoluzione e la mia proposta nasce da questi riferimenti.

Spiegazione:
In bulk erosion, the rate of water penetration into the solid device exceeds the rate at which the polymer transforms into water soluble materials. As the water enters the polymer, erosion transpires throughout the whole volume. Cracks and crevices form in the polymer, and it rapidly disintegrates. Meanwhile, the drug diffuses out of the polymer as more and more cracks are formed in the material.

On the other hand, surface erosion presents a different outlook. The rate at which water enters the polymer device is less than the rate of polymer transformation to water-soluble materials. The surface area of the polymer matrix limits the process. In time, the device becomes thinner while maintaining its structural integrity. To achieve this condition, the polymer needs to have a certain degree of hydrophobicity.

Selected response from:

Moby
Italy
Local time: 01:39
Grading comment
Many thanks for the help.
4 KudoZ points were awarded for this answer



Summary of answers provided
3polimero a dissoluzione rapida
Moby


Discussion entries: 1





  

Answers


20 hrs   confidence: Answerer confidence 3/5Answerer confidence 3/5
polimero a dissoluzione rapida


Explanation:
è la soluzione migliore che mi è venuta in mente senza essere un'esperta di chimica e farmaceutica. Ho trovato su internet la spiegazione sotto riportata per la differenza tra bulk e surface erosion di rivestimenti polimerici di farmaci. Sui siti italiani si parla di dissoluzione, dissoluzione intrinseca e velocità di dissoluzione e la mia proposta nasce da questi riferimenti.

Spiegazione:
In bulk erosion, the rate of water penetration into the solid device exceeds the rate at which the polymer transforms into water soluble materials. As the water enters the polymer, erosion transpires throughout the whole volume. Cracks and crevices form in the polymer, and it rapidly disintegrates. Meanwhile, the drug diffuses out of the polymer as more and more cracks are formed in the material.

On the other hand, surface erosion presents a different outlook. The rate at which water enters the polymer device is less than the rate of polymer transformation to water-soluble materials. The surface area of the polymer matrix limits the process. In time, the device becomes thinner while maintaining its structural integrity. To achieve this condition, the polymer needs to have a certain degree of hydrophobicity.



Moby
Italy
Local time: 01:39
Native speaker of: Native in GermanGerman, Native in ItalianItalian
PRO pts in pair: 28
Grading comment
Many thanks for the help.
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