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English to Japanese translations [PRO] Medical - Medical (general)
English term or phrase:in equipoise with
The strategy is to prove that AVS is as good as Synvisc and better in ease of use. Physicians are not in equipoise with a placebo. For these reasons, we went for an active control and believe that Synvisc is appropriate.
The null hypothesis (H0) can never be taken for granted... it is like the baseline for statistical comparison (and that baseline can be distorted or not properly reflected due to experimenter/subject/instrument factors). Thanks for sharing anyways.
To Katalin Horvath McClure-san: I wouldn't call my reading "not making sense at all"... In experimental studies, a placebo group CAN show significant effects. WHY? This has to do with test reliability and subject pre-test conditions.
22:25 Mar 21, 2006
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Answers
1 day14 hrs confidence:
explanation
Explanation: You should look for the Japanese equivalent of "clinical equipoise", because this is what your text is referring to. (I am not sure how to say that in Japanese.)
What the sentence is saying that using a placebo in a trial does not satisfy the requirements of clinical equipoise. Active control does, that's why they decided to do trial that way.
Clinical equipoise is a collective uncertainty, where the physicians don't know which treatment is better for a certain illness.
A placebo is not a treatment, it's like a "pretend treatment" so they would be testing one experimental treatment against "no treatment". Clinical equipoise usually assumes that there are at least two treatments known to the phisicians, but they don't nknow which one is better, or the opinion of the community is divided: some doctors prefer treatment A, others prefer B.
The two treatments can be compared in a randomized trial, and at the end of the trial, it is expected that the "clinical equipoise" will be disturbed, in other words, the colllective opinion will turn towards one of the treatments. In other words, the trial would convince the community one way or the other.
You can read more about this at the website below.
I hope this helps finding the Japanese equivalent of this idea.
Physicians are certain that a treatment of placebo will not be as effective as that of Synvisc
Explanation: --- Physicians are certain that a treatment of placebo will not be as effective as that of Synvisc. (So, they can rule out placebo as a treatment option)
OR
--- Physicians are not unsure that a treatment of placebo will give the same effects as does Synvisc (which is an effective drug). (So, they can rule out placebo as a treatment option)
I agree with Katalin Horvath McClure-san that “equipoise” here refers to the more technical term “clinical equipoise”.
To be “in equipoise with” treatment options means that you can not be sure which particular treatments / therapies are more effective than the others.
A placebo (e.g. glucose solution) gives no true pharmacological effects. It is often given to patients in a control group. If results/outcomes for the placebo group are the same as that of the experimental groups (those given AVS or Synvisc treatment), it means AVS or Synvisc is no good (for example).
In this context (and based on PubMed sources), however, Synvisc DOES have a significant effect on the patients compared with placebo "treatment."
Please refer to the followings on Synvisc's effects (better than that of a placebo):
Hyaluronic acid injections for knee osteoarthritisWobig et al,6 1998, Three injections of Synvisc, saline placebo ... Synvisc was found to be superior to placebo: pain and use of rescue medication were both ... www.cfpc.ca/cfp/2004/Feb/vol50-feb-cme-2.asp - 76k - Cached - Similar pages - Remove result
Effects of a hydroxyl radical scavenger on delayed ischemic ...Drug administration (4 g AVS or 4 g glucose as placebo; infused intravenously for 6-8 hours once a day) was begun within 5 days post-SAH and continued for ... www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve& db=PubMed&list_uids=8622153&dopt=Abstract - Similar pages - Remove result
*** If the investigators can prove that AVS is as good as Synvisc (that is, has a signficant effect compared with placebo), then the hypothesis that AVS is an effective treatment can be established.
*** That’s why physicians can at least kick placebo out of their options list.
[PDF] Therapeutic Beneficence and Patient Recruitment in Randomized ...
File Format: PDF/Adobe Acrobat
When a patient is in equipoise with respect to. an approved trial, randomization offers the ... placebo, but this outcome is uncertain. All the partici- ...
taylorandfrancis.metapress.com/ index/LLCTNTARRW4EL5KK.pdf - Similar pages - Remove result
Breast Cancer Update - BCU Surgeons Vol.2 Issue 2 - 2 visits - 9:48am
Researchers often state that they must be “in equipoise with the options”: all of the randomization arms are essentially equivalent, until proven otherwise. ... www.breastcancerupdate.com/ bcu2003/bcu2_surgeons/editor.htm - 15k - Cached - Similar pages - Remove result
Naikei Wong Local time: 06:54 Specializes in field Native speaker of: English, Chinese PRO pts in category: 50
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