retro-inverso peptidomimetics

Latvian translation: retro-invertētie imitētājpeptīdi

13:09 Oct 30, 2007

English to Latvian translations [PRO]
Medical - Medical: Pharmaceuticals

English term or phrase: retro-inverso peptidomimetics

By "peptide" the inventors include not only molecules in which amino acid residues are joined by peptide (-CO-NH-) linkages but also molecules in which the peptide bond is reversed. Such retro-inverso peptidomimetics may be made using methods known in the art, for example such as those described in Meziere et al (1997) J. Immunol. 159,3230-3237, incorporated herein by reference. This approach involves making pseudopeptides containing changes involving the backbone, and not the orientation of side chains. Meziere et al (1997) show that, at least for MHC class II and T helper cell responses, these pseudopeptides are useful. Retro-inverse peptides, which contain NH-CO bonds instead of CO-NH peptide bonds, are much more resistant to proteolysis.

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Local time: 09:08

Latvian translation:retro-invertētie imitētājpeptīdi

Explanation:
Visi peptīdi, kuri, salīdzinot ar peptīdu-priekšteci, ietver invertēti jeb apvērstā kārtībā piesaistītas sastāvdaļas (no sekvences beigām uz sākumu) šā vai tā ir modificēti.

imitētājpeptīdi vai modificētie peptīdi

Tā kā ir milzīgs skaits peptīdu un to ieguves un sintēzes metodes pilnveidojas katru dienu, domāju, nav nepieciešamības mainīt retro-invertētie peptīdi, jo tādā veidā iespējams arī paturēt vispārlietojamo abreviāciju (RI), kas ļauj tos atpazīt.

Diemžēl vairāk nav laika.

Retro-inversion is a way of protecting peptide substances against proteolysis. It entails retro-inverting those peptide bonds most susceptible to enzymatic hydrolysis by inverting the direction of the peptide bonds. The "retro-inverso peptides" are structural isomers of the reference peptides and as such preserve their biological activity while being more resistant to enzymatic hydrolysis.

A peptidomimetic is a small protein-like chain designed to mimic a peptide. They typically arise from modification of an existing peptide in order to alter the molecule's properties. For example, they may arise from modifications to change the molecule's stability or biological activity.

Selected response from:

Inese Poga-Smith
Canada
Local time: 02:08

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Paldies:)
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retro-invertētie imitētājpeptīdi

Inese Poga-Smith

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retro-invertētie imitētājpeptīdi

Inese Poga-Smith
Canada
Local time: 02:08
Specializes in field
Native speaker of: Latvian
PRO pts in category: 87

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Paldies:)

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