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  3. Medical: Pharmaceuticals

aberrantly express

Latvian translation: anomāli (aberāli) ekspresē

09:32 Oct 31, 2007
English to Latvian translations [PRO]
Medical - Medical: Pharmaceuticals
English term or phrase: aberrantly express
The peptide of the invention is particularly useful in immunotherapeutic methods to target and kill cells which aberrantly express polypeptides that form the basis for the present peptides of the invention. Since these specific peptides consisting of the given amino acid sequences bind to HLA-DR it is preferred that the peptides of the invention are ones which bind HLA-DR and when so bound the HLA-DR-peptide complex, when present on the surface of a suitable antigen-presenting cell, is capable of eliciting the production of a CTL which recognises a cell which aberrantly expresses a polypeptide comprising the given amino acid sequence.

In one embodiment of the present invention, the peptide of the present invention comprises the 80 N-terminal amino acids of the HLA-DR antigen-associated invariant chain (p33, in the following ”Ii”) as derived from the NCBI, GenBank Accession-number X00497 (see also below).

By "aberrantly expressed" we include the meaning that the polypeptide is over-expressed compared to normal levels of expression or that the gene is silent in the tissue from which the tumour is derived but in the tumour it is expressed. By "over-expressed" we mean that the polypeptide is present at a level at least 1.2 x that present in normal tissue; preferably at least 2 x and more preferably at least 5 x or 10 x the level present in normal tissue.
Vents Villers
Local time: 05:28
Latvian translation:anomāli (aberāli) ekspresē
Explanation:
Līdzigos gadījumos ticis vienkārši lietots "ekspresē"


Ekspresē ar novirzēm, ekspresē anomāli, espresē aberāli, u.c.

Izceļojot no aizkrūts dziedzera uz perifēriju, T limfocīti ekspresē audu saderības kompleksa II klases antigēnus un CD4 vai CD8 antigēnus. Ir vairākas funkcionāli atšķirīgas T limfocītu populācijas: T lizētājšūnas, kas ekspresē CD4 antigēnus, T citotoksiskās šūnas, kas ekspresē CD8 proteīnu, T nomācējšūnas, kuru esamība tiek apšaubīta.

CD4 saistās ar MHC II klases molekulām, ko ekspresē antigēnprezentētājas šūnas. CD8 saistās ar MHC I klases molekulām antigēnprezentētājšūnu membrānā.

un citos dok.

5) Par Padomes lēmumu, ar ko noraida Eiropas Komisijas priekšlikumu Padomes lēmumam par pagaidu aizliegumu izplatīt Ungārijas tirgū ģenētiski modificētu kukurūzu (Zea mays L. līnija MON 810, kas ekspresē Bt cryIA(b) gēnu) atbilstoši Eiropas Parlamenta un Padomes Direktīvai 2001/18/EK.
Selected response from:

Inese Poga-Smith
Canada
Local time: 22:28
Grading comment
:)
4 KudoZ points were awarded for this answer



Summary of answers provided
4anomāli (aberāli) ekspresē
Inese Poga-Smith


  

Answers


5 hrs   confidence: Answerer confidence 4/5Answerer confidence 4/5
anomāli (aberāli) ekspresē


Explanation:
Līdzigos gadījumos ticis vienkārši lietots "ekspresē"


Ekspresē ar novirzēm, ekspresē anomāli, espresē aberāli, u.c.

Izceļojot no aizkrūts dziedzera uz perifēriju, T limfocīti ekspresē audu saderības kompleksa II klases antigēnus un CD4 vai CD8 antigēnus. Ir vairākas funkcionāli atšķirīgas T limfocītu populācijas: T lizētājšūnas, kas ekspresē CD4 antigēnus, T citotoksiskās šūnas, kas ekspresē CD8 proteīnu, T nomācējšūnas, kuru esamība tiek apšaubīta.

CD4 saistās ar MHC II klases molekulām, ko ekspresē antigēnprezentētājas šūnas. CD8 saistās ar MHC I klases molekulām antigēnprezentētājšūnu membrānā.

un citos dok.

5) Par Padomes lēmumu, ar ko noraida Eiropas Komisijas priekšlikumu Padomes lēmumam par pagaidu aizliegumu izplatīt Ungārijas tirgū ģenētiski modificētu kukurūzu (Zea mays L. līnija MON 810, kas ekspresē Bt cryIA(b) gēnu) atbilstoši Eiropas Parlamenta un Padomes Direktīvai 2001/18/EK.

Example sentence(s):
  • http://72.14.205.104/search?q=cache:BvdcrbqnuTIJ:www.emea.europa.eu/vetdocs/PDFs/EPAR/Vaxxitek/075502lv1.pdf+ekspres%C4%93&hl=lv&ct=clnk&cd=7&gl=lv

    Reference: http://www.vidm.gov.lv/lat/es_vides_informacija/ministru_pad...
    Reference: http://72.14.205.104/search?q=cache:CqESr3yEvDsJ:bmc.myphoto...
Inese Poga-Smith
Canada
Local time: 22:28
Specializes in field
Native speaker of: Latvian
PRO pts in category: 87
Grading comment
:)
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