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English to Portuguese translations [PRO]
Medical - Medical (general) | | English term or phrase: FLIPPED PATTERN | Lactic Dehydrogenase (LDH)
This enzyme contributes to carbohydrate metabolism and is found in the heart, kidneys, and red blood cells. LDH is useful for the late diagnosis of an MI after the CK–MB has returned to normal. The predictive value of measuring LDH to determine if myocardial damage has occurred is 90% to 95%. Increased LDH activity begins to appear 10 to 12 hours after an MI, peaks within 48 to 72 hours, and remains elevated for as long as 14 days. The LDH is particularly necessary to assess when diagnosing MIs after the initial 24 hours of onset and the CK–MB isoenzyme peak is missed. LDH is composed of five isoenzymes, with the majority of LDH1 and LDH2 found in myocardial cells and rising after an acute MI. LDH1 and LDH2 are known as the cardiac fraction, with serum levels of LDH1 normally LESS than LDH2. With an MI, both LDH1 and LDH2 levels will rise, with the LDH1 level increasing before there is an increase in the total LDH. The LDH1 level will actually exceed or become greater than the LDH2 level. This response is known as a “FLIPPED PATTERN,” or a REVERSAL of the LDH1 and LDH2 levels, confirming the diagnosis of an MI. To review, under healthy, normal circumstances, LDH2 results are generally higher than LDH1 levels. In the case of an MI, the opposite situation occurs. |
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 Teresa Borges
Belgium
Local time: 22:37
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