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RCR

Romanian translation: retrovirus cu potential de replicare

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GLOSSARY ENTRY (DERIVED FROM QUESTION BELOW)

English term or phrase:	RCR
Romanian translation:	retrovirus cu potential de replicare
Entered by:	Antonia Toth

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07:48 Jan 15, 2011

English to Romanian translations [PRO]
Medical - Medical: Pharmaceuticals / Acronym

English term or phrase: RCR

This acronym occurs in a file decribing laboratory tests:
- RCR RNA
- RCR serum
- Baseline RCR
- RCR DNA
I need to know the meaning of the acronym before I venture into translating it:))

Janos Fazakas KudoZ activity Questions: 193 (5 open) (2 closed without grading) Answers: 416
Local time: 17:35

retrovirus cu potential de replicare

Explanation:
Contamination by replication-competent retrovirus (RCR) is one of the most important safety issues of retrovirus vector products for gene therapy clinical research

http://www.virushunters.net/showabstract.php?pmid=15536044

Briefing Document — Testing for Replication Competent Retrovirus

http://www.fda.gov/downloads/AdvisoryCommittees/CommitteesMe...

Retrovirusurile cu potential de replicare pot induce o varietate de tumori prin activarea insertionala a genelor celulare;

http://ebooks.unibuc.ro/biologie/oncoproteine/I.htm

Selected response from:

Antonia Toth
Local time: 18:35

Grading comment

Selected automatically based on peer agreement.
4 KudoZ points were awarded for this answer

Summary of answers provided

3 +2

retrovirus cu potential de replicare

Antonia Toth

5 -1

random coefficient regression (RCR)

Constantinos Faridis

Summary of reference entries provided

retrovirus cu potenţial de replicare

Mihaela Petrican

Discussion entries: 4

Answers

13 mins confidence:

peer agreement (net): -1

rcr random coefficient regression (RCR)

Explanation:
We used a random coefficient regression (RCR) model to estimate growth parameters for the time series of observed serum glucose levels in the Replicate 1 of ...
www.ncbi.nlm.nih.gov › Journal List › BMC Genet › v.4(Suppl 1); 2003
#
31 Dec 2003 ... Use of a random coefficient regression (RCR) model to estimate growth parameters ... parameters for the time series of observed serum glucose levels in ... baseline values, but also on the course of the trait over time. ...
www.biomedcentral.com/1471-2156/.../s5 - Προσωρινά αποθηκευμένη
#
Kidney International - The acute-phase response varies with time ...
- [ Μετάφραση αυτής της σελίδας ]
από GA Kaysen - 2000 - Γίνεται αναφορά σε 124 - Σχετικά άρθρα
A random coefficient regression analysis was used to assess the association of ... Furthermore, the serum albumin concentration also correlated with normalized .... In the fitted model, this predicted baseline was then added to the ...
www.nature.com › Journal home › Archive › Original Articles

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Note added at 21 λεπτά (2011-01-15 08:10:40 GMT)
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aleatoare coeficient de regresie

Constantinos Faridis
Greece
Local time: 18:35
Native speaker of: Greek

42 mins confidence:

peer agreement (net): +2

rcr

retrovirus cu potential de replicare

Antonia Toth
Local time: 18:35
Works in field
Native speaker of:

Romanian
PRO pts in category: 71

Grading comment

Selected automatically based on peer agreement.

Reference comments

1 hr peer agreement (net): +1

Reference: retrovirus cu potenţial de replicare

Reference information:
Antonia are dreptate, soluţia este cât se poate de plauzibilă în contextul dat. Baseline se referă la valorile de referinţă/determinările de la momentul iniţial al studiului.

Peripheral blood mononuclear cells (PBMCs) in five of the six patients at dose level 2 and two of three patients at dose level 3 were tested for the presence of replication-competent retroviruses (RCR) using real-time polymerase chain reaction (PCR), either at week 4 (dose level 2) or at week 6 (dose level 3).

Testing for the presence of RCR was performed on DNA extracted from peripheral blood lymphocytes of patients, obtained at baseline (before vector infusion) and at either 4 weeks (dose levels 1 and 2) or 6 weeks (dose level 3) after treatment. The assay was designed to use PCR to detect the presence of RCR DNA sequences after transfusion.
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2756987/

Contamination by replication-competent retrovirus (RCR) is one of the most important safety issues of retrovirus vector products for gene therapy clinical research. To improve the sensitivity of RCR detection and to shorten the assay period, we have developed a novel RCR detection method (infectivity RT-PCR method) based on real-time quantitative reverse transcription-polymerase chain reaction (RT-PCR) in combination with virus infection and a novel virus concentration method using polyethyleneimine (PEI)-conjugated magnetic beads. In this method, permissive cells were infected with RCR samples, and amplified RCR in the culture supernatants was adsorbed by PEI-beads. Then RCR RNA extracted from PEI-beads was quantified by real-time RT-PCR.
http://www.ncbi.nlm.nih.gov/pubmed/15536044

Mihaela Petrican
Italy
Specializes in field
Native speaker of:

Romanian
PRO pts in category: 490

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Changes made by editors

Jan 29, 2011 - Changes made by Antonia Toth:
Created KOG entry	KudoZ term => KOG term

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RCR

Romanian translation: retrovirus cu potential de replicare

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RCR

Romanian translation: retrovirus cu potential de replicare

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KudoZ™ translation helpThe KudoZ network provides a framework for translators and others to assist each other with translations or explanations of terms and short phrases.

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