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enediyne warhead

Russian translation: ендииновая группа

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GLOSSARY ENTRY (DERIVED FROM QUESTION BELOW)
English term or phrase:enediyne warhead
Russian translation:ендииновая группа
Entered by: katerina24
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12:41 Sep 7, 2006
English to Russian translations [PRO]
Medical - Biology (-tech,-chem,micro-)
English term or phrase: enediyne warhead
The calicheamicins contain an enediyne warhead (Fig. 1) that is activated by reduction of the -S-S- bond causing breaks in double-stranded DNA.

Калихеамицин содержит an enediyne warhead, который активируется восстановлением S-S связи, приводящей к разрыву двунитевой ДНК.
katerina24
Local time: 10:44
ендииновая группа
Explanation:
"The enediyne group is often called a warhead because it is ready to cyclize, forming benzene via a highly reactive 1,4 benzeniod diradical intermediate. This diradical intermediate is responsible for the oxidative DNA cleavage. This cyclization process is named the Bergman cycloaromatization reaction. The enediyne group readily cyclizes via a diradical intermediate that cleaves the DNA, giving rise to enediynes’ powerful antitumor activity".
http://jlstasal.myweb.uga.edu/
Selected response from:

Sergei_A
Local time: 03:44
Grading comment
спасибо.
3 KudoZ points were awarded for this answer

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Summary of answers provided
4 +3ендииновая группаSergei_A


  

Answers


33 mins   confidence: Answerer confidence 4/5Answerer confidence 4/5 peer agreement (net): +3
ендииновая группа


Explanation:
"The enediyne group is often called a warhead because it is ready to cyclize, forming benzene via a highly reactive 1,4 benzeniod diradical intermediate. This diradical intermediate is responsible for the oxidative DNA cleavage. This cyclization process is named the Bergman cycloaromatization reaction. The enediyne group readily cyclizes via a diradical intermediate that cleaves the DNA, giving rise to enediynes’ powerful antitumor activity".
http://jlstasal.myweb.uga.edu/

Sergei_A
Local time: 03:44
Specializes in field
Native speaker of: Russian
PRO pts in category: 90
Grading comment
спасибо.

Peer comments on this answer (and responses from the answerer)
agree  Pavel Venediktov: Чтобы передать warhead модно сказать ендииновую _активную_ группу.
1 hr
  -> или "фунциональную". Спасибо:)

agree  callingblind
6 hrs
  -> Спасибо:)

agree  Smantha
9 hrs
  -> Спасибо:)
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