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15:19 Jan 15, 2008
English to Russian translations [PRO] Science - Biology (-tech,-chem,micro-)
English term or phrase:kernal mutation
The sequence diversity of one or more monomer domains can be expanded by mutating the monomer domain with site-directed mutagenesis, random mutation, pseudorandom mutation, defined **kernal mutation**, codon-based mutation, and the like.
Explanation: This gene circuit constitutes a ***"kernel,"*** which is evolutionarily inflexible and performs essential regulatory functions in building a body part (Davidson and Erwin 2006Go). Analyses of vertebrate heart development revealed that the differentiation of cardiac muscle cells and morphogenesis of the heart are governed by this heart ***kernel gene*** regulatory network (Cripps and Olson 2002Go; Harvey 2002Go; Buckingham et al. 2005Go). An important question to be answered about the formation of the heart in vertebrates and other chordates is how this ***kernel*** is turned on at the earliest stages of the heart cell specification process to establish the heart field. http://www.genesdev.org/cgi/content/full/20/19/2634