English: knock-out experiment Russian translation: метод генного нокаута 
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| GLOSSARY ENTRY (DERIVED FROM QUESTION BELOW) | | English term or phrase: | knock-out experiment | | Russian translation: | метод генного нокаута | | Entered by: | Yuliya Panas |
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English to Russian translations [PRO]
Science - Genetics / Experiments | | English term or phrase: knock-out experiment | In a knockout experiment, an organism is engineered to lack the expression and activity of one or more genes. This is done through genetic manipulation, using snipping enzymes, crossover activity, or binding to either eliminate the specific gene sequence or make it unusable. Once the extracellular DNA is changed, it is reintroduced into embryonic stem cells, where the engineered copy is encouraged to replace the organism's own gene. The infected stem cells are injected into blastocysts which are implanted in surrogate mothers.
Knockout experiments are often performed in order to determine the functional role of a specific gene in the organism by studying the defects caused by the resulting mutation. Knockout experiments are especially useful for understanding the genes that code for the protein parts essential for the functioning of molecular machines.
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| | Clarification request(s) and responseYuliya Panas: 12:22pm Sep 25, 2006: Sorry, knock-out experiment -
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| | Selected response from:
erika rubinstein
Germany
| Note from asker to answerer| 4 KudoZ points were awarded for this answer |
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8 mins confidence:   peer agreement (net): +1 |
4 hrs confidence: |
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