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protofected

Russian translation: внедренные в митохондрии


GLOSSARY ENTRY (DERIVED FROM QUESTION BELOW)
English term or phrase:protofected
Russian translation:внедренные в митохондрии
Entered by: Igor_2006
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17:09 Nov 3, 2009Login or register (free) for more options.
English to Russian translations [PRO]
Science - Genetics
English term or phrase: protofected
Если protofection переводить по аналогии с transfection - протофекция, то как быть с protofected?

Clearly delineate the successful cleavage of native genes by ***protofected*** restriction enzymes.

Спасибо.
Sophia Shishatskaya
Russian Federation
Local time: 06:39
генно-инженерные рестриктазы, экспрессирующиеся в митохондриях
Explanation:
Мне кажется, что ответ Алекса не совсем точен. "protofection" означает внедрение генно-инженерных структур именно в митохондрии, а не вообще в клетки.

... "ProtoFection" uses recombinant human mitochondrial transcription factor A (TFAM) engineered with an N-terminal protein transduction domain (PTD) followed by the SOD2 mitochondrial localization signal (MLS) to deliver mtDNA cargo to the mitochondria of living cells. MTD-TFAM (MTD = PTD + MLS = "mitochondrial transduction domain") binds mtDNA and rapidly transports it across plasma membranes to mitochondria. For therapeutic proof-of-principle we tested ProtoFection technology in Parkinson's disease cybrid cells ...
Selected response from:

Igor_2006
Russian Federation
Local time: 06:39
Grading comment
Спасибо!
4 KudoZ points were awarded for this answer



Summary of answers provided
4генно-инженерные рестриктазы, экспрессирующиеся в митохондриях
Igor_2006
3рестрекционные ферменты, синтез которых осущетсвляют гены, внедренные в клетку путем трансфекции
Alex Senkevich


  

Answers


41 mins   confidence: Answerer confidence 3/5Answerer confidence 3/5
рестрекционные ферменты, синтез которых осущетсвляют гены, внедренные в клетку путем трансфекции


Explanation:
!

Alex Senkevich
Belarus
Local time: 01:39
Meets criteria
Native speaker of: Native in RussianRussian
PRO pts in category: 4
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12 hrs   confidence: Answerer confidence 4/5Answerer confidence 4/5
генно-инженерные рестриктазы, экспрессирующиеся в митохондриях


Explanation:
Мне кажется, что ответ Алекса не совсем точен. "protofection" означает внедрение генно-инженерных структур именно в митохондрии, а не вообще в клетки.

... "ProtoFection" uses recombinant human mitochondrial transcription factor A (TFAM) engineered with an N-terminal protein transduction domain (PTD) followed by the SOD2 mitochondrial localization signal (MLS) to deliver mtDNA cargo to the mitochondria of living cells. MTD-TFAM (MTD = PTD + MLS = "mitochondrial transduction domain") binds mtDNA and rapidly transports it across plasma membranes to mitochondria. For therapeutic proof-of-principle we tested ProtoFection technology in Parkinson's disease cybrid cells ...


    Reference: http://www.mfoundation.org/forums/showthread.php?t=1390
Igor_2006
Russian Federation
Local time: 06:39
Meets criteria
Specializes in field
Native speaker of: Native in RussianRussian
PRO pts in category: 7
Grading comment
Спасибо!
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