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transcriptional signature

Russian translation: транскрипционная сигнатура

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14:56 Jan 10, 2011

English to Russian translations [PRO]
Science - Genetics

English term or phrase: transcriptional signature

Another area where a simple method of transcriptional profiling can be extremely instrumental is characterization of cells and organisms that underwent genetic modifications (for example transgenic animals carrying a modified version of the gene, overexpressing genes or missing genes (knock-outs)). Such cells and organisms often display an altered transcription profile as a result of the modified function of the targeted gene or as a compensating effect. Such changes can point out to the function of the gene by placing it to the particular pathway defined by the identity of the differentially expressed genes. It may help to define a **transcriptional signature** of alteration in particular genes and to use such signatures to define genetic modification in a particular disease by comparison of the transcriptional changes in cells or tissues obtained from the disease-affected organisms versus a database of **transcriptional signatures**.
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Nitrogen

Russian translation:транскрипционная сигнатура

Explanation: