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Medical - Medical: Pharmaceuticals | | English term or phrase: blank vehiculum | The HPLC method is also suitable to act as an identification method of the active substance. The retention time and peak area must match that of the reference standard. As this procedure is not generally accepted as the sole method of identification, an additional color reaction is performed. The *blank vehiculum* alone does not respond. No further validation is needed, while this reaction is well known from the literature as a specific test for secondary amines.
The identification method for the coloring matters in the capsule shell is quite common and straightforward and no validation report is provided. It is basically the same as the method described in the Ph. Fr.XI for the identification of dyes in empty capsules and is in use for many years by the applicant. |
|  Maxim PolukhinKudoZ activityQuestions: 262 ( 4 open) ( 1 without valid answers) ( 14 closed without grading) Answers: 31
| | Local time: 21:41
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| | Russian translation:плацебо (смесь вспомогательных веществ) | Explanation:
http://en.wiktionary.org/wiki/vehiculum
vehiculum: means of transport; vehicle
т .е. vehiculum - носитель.
blank vehiculum здесь может быть и матрица (плацебо) и холостой раствор (растворитель проб).
И то и другое исследуют в таких случаях. Но, поскольку раствор плацебо включает в себя и растворитель и вспомогательные вещества (матрицу, плацебо), то достаточно проверить этот раствор на отсутствие мешающих пиков. |
| Selected response from:
 Leila Usmanova
Local time: 21:41
| Grading comment | 4 KudoZ points were awarded for this answer |
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22 mins confidence:   peer agreement (net): +6 | |
The translation workplace 
