KudoZ home » English to Russian » Medical (general)

ALC

Russian translation: Минимальная летальная концентрация

Advertisement

Login or register (free and only takes a few minutes) to participate in this question.

You will also have access to many other tools and opportunities designed for those who have language-related jobs
(or are passionate about them). Participation is free and the site has a strict confidentiality policy.
GLOSSARY ENTRY (DERIVED FROM QUESTION BELOW)
English term or phrase:ALC
Russian translation:Минимальная летальная концентрация
Entered by: Natalie
Options:
- Contribute to this entry
- Include in personal glossary

16:18 Feb 14, 2009
English to Russian translations [PRO]
Medical - Medical (general) / MSDS
English term or phrase: ALC
Уважаемые, перевожу MSDS и встретилась фраза Inhalation 4 hour ALC: > 709,000 ppm in rats
Гуголь учит, что ALC = approximate lethal concentration.
Вопрос - надо ли это переводить, или так и оставить ALC без перевода, как, скажем LC50, LD50?
Спасибо
Enote
Local time: 01:36
Минимальная летальная концентрация/доза
Explanation:
Да, судя по ссылкам, все так и есть. Однако в русскоязычных статьях, увы, практически не встречается, что и понятно (на слух странно воспринимается "приблизительная смертельная/летальная концентрация/доза)".

http://www.inchem.org/documents/eintro/eintro/abreviat.htm
ALC approximate lethal concentration
ALD approximate lethal dose

На основании ниже приведенной ссылки:
http://www3.interscience.wiley.com/journal/112227859/abstrac...
The approximiate lethal dose (ALD) to rats following oral administration of nine chemicals was determined. The ALD (lowest dose at which death was produced) for each chemical was used to define the general order of toxicity as being either extremely, highly, moderately, slightly, or practically non-toxic. For each of the nine chemicals tested, the category indicated by the ALD was identical with the category determined in the more extensive LD50 studies. In this study, an average of 6.8 rats was needed to determine the ALD while an average of 56.3 rats was needed to determine the LD50.

http://dic.academic.ru/dic.nsf/enc_medicine/11239/Доза
До́за смерте́льная минима́льная (DLM; d. letalis minima) — Д., вызывающая за фиксированный период времени гибель единичных, наиболее чувствительных подопытных животных; принимается за нижний предел Д. с.



--------------------------------------------------
Note added at 12 hrs (2009-02-15 04:36:30 GMT)
--------------------------------------------------

Учитывая вопрос, в котором указан ингаляционный путь введения вещества, можно воспользоваться следующими определениями:
http://orgchem.colorado.edu/safety/tox.html
Hazards of Chemicals: Toxicology Nomenclature
LD and LC
LD50 is lethal dose 50. This is the single dose of a toxic substance administered by any route (other than by inhalation) that causes the death of 50% of an animal population. LDLo is lethal dose low—the lowest dose of a substance reported to have caused death in humans or animals.

LC50 is lethal concentration 50. It is the concentration of a material in air that kills 50% of a group of test animals when administered as a single exposure in a specific time period (usually 1 hour). Note that lethal concentration values are used when the route of administration is by inhalation (rather than oral, dermal, etc.) whereas LD values are used for all routes except inhalation. LC values are often expressed as parts of material per million parts of air (ppm).

В других случаях определения тоже практически идентичны:
http://www.bugwood.org/PAT/Glossary.html
Approximate Lethal Concentration (ALC) – An estimate of the concentration of a pesticide in air or water which is capable of killing a test animal. See also… MLC
Approximate Lethal Dose (ALD) – An estimate of the dose of a pesticide which is necessary to kill a test animal. See also… MLD

Хотя, конечно, следует учитывать экспозицию:
http://refrigerants.dupont.com/Suva/en_US/pdf/k05740.pdf
The Approximate Lethal Concentration (ALC) and the
Lethal Concentration in “x” percent (LCx) tests in laboratory
animals are often used to assess acute lethality. During the
ALC or LCx tests, the animals are monitored for any clinical
signs that might signal adverse effects in the test animals,
including irritation, behavioral changes, anesthetic effects
etc. The test typically includes a 4-hr inhalation with a 2-wk
follow up period. If the acute lethality endpoint were used
to set exposure standards, appropriate uncertainty, extrapolation
or safety factors would be applied to values determined
in experimental animals.

Но в случаях с введением веществ ингаляционным путем (или путем вдыхания)применяют именно понятие концентрации в качестве дозы ( а как иначе измерить вдыхаемую дозу - только путем учета концентрации):
http://hes.pbh.med.kyoto-u.ac.jp/pfcreview/PEN_09004a2f80006...
Telomer B:
Inhalation ALC: 6 mg/L in rats
Oral LD50: >17,000 mg/kg in rats
Telomer B is not a skin irritant, is untested for eye
irritancy, and is not a skin sensitizer in animals. A
single inhalation exposure produced labored respiration,
weight loss, salivation, and prostration. A single
ingestion exposure produced labored respiration, weight
loss, and prostration.

http://www.tedpella.com/msds_html/81500msd.htm
Results of component toxicity test performed: (Oral Acute ALD (Approximate Lethal Dose), Rats): >1500 mg/kg. (Inhalation ALC, Rats): 4 hr: 383,000 ppm.
Selected response from:

Ann Nosova
United States
Local time: 18:36
Grading comment
Большое спасибо.
Столько ссылок...
4 KudoZ points were awarded for this answer

Advertisement


Summary of answers provided
3 -1Минимальная летальная концентрация/доза
Ann Nosova
Summary of reference entries provided
-stasbetman
Разъяснение
Natalie

Discussion entries: 6





  

Answers


4 hrs   confidence: Answerer confidence 3/5Answerer confidence 3/5 peer agreement (net): -1
alc
Минимальная летальная концентрация/доза


Explanation:
Да, судя по ссылкам, все так и есть. Однако в русскоязычных статьях, увы, практически не встречается, что и понятно (на слух странно воспринимается "приблизительная смертельная/летальная концентрация/доза)".

http://www.inchem.org/documents/eintro/eintro/abreviat.htm
ALC approximate lethal concentration
ALD approximate lethal dose

На основании ниже приведенной ссылки:
http://www3.interscience.wiley.com/journal/112227859/abstrac...
The approximiate lethal dose (ALD) to rats following oral administration of nine chemicals was determined. The ALD (lowest dose at which death was produced) for each chemical was used to define the general order of toxicity as being either extremely, highly, moderately, slightly, or practically non-toxic. For each of the nine chemicals tested, the category indicated by the ALD was identical with the category determined in the more extensive LD50 studies. In this study, an average of 6.8 rats was needed to determine the ALD while an average of 56.3 rats was needed to determine the LD50.

http://dic.academic.ru/dic.nsf/enc_medicine/11239/Доза
До́за смерте́льная минима́льная (DLM; d. letalis minima) — Д., вызывающая за фиксированный период времени гибель единичных, наиболее чувствительных подопытных животных; принимается за нижний предел Д. с.



--------------------------------------------------
Note added at 12 hrs (2009-02-15 04:36:30 GMT)
--------------------------------------------------

Учитывая вопрос, в котором указан ингаляционный путь введения вещества, можно воспользоваться следующими определениями:
http://orgchem.colorado.edu/safety/tox.html
Hazards of Chemicals: Toxicology Nomenclature
LD and LC
LD50 is lethal dose 50. This is the single dose of a toxic substance administered by any route (other than by inhalation) that causes the death of 50% of an animal population. LDLo is lethal dose low—the lowest dose of a substance reported to have caused death in humans or animals.

LC50 is lethal concentration 50. It is the concentration of a material in air that kills 50% of a group of test animals when administered as a single exposure in a specific time period (usually 1 hour). Note that lethal concentration values are used when the route of administration is by inhalation (rather than oral, dermal, etc.) whereas LD values are used for all routes except inhalation. LC values are often expressed as parts of material per million parts of air (ppm).

В других случаях определения тоже практически идентичны:
http://www.bugwood.org/PAT/Glossary.html
Approximate Lethal Concentration (ALC) – An estimate of the concentration of a pesticide in air or water which is capable of killing a test animal. See also… MLC
Approximate Lethal Dose (ALD) – An estimate of the dose of a pesticide which is necessary to kill a test animal. See also… MLD

Хотя, конечно, следует учитывать экспозицию:
http://refrigerants.dupont.com/Suva/en_US/pdf/k05740.pdf
The Approximate Lethal Concentration (ALC) and the
Lethal Concentration in “x” percent (LCx) tests in laboratory
animals are often used to assess acute lethality. During the
ALC or LCx tests, the animals are monitored for any clinical
signs that might signal adverse effects in the test animals,
including irritation, behavioral changes, anesthetic effects
etc. The test typically includes a 4-hr inhalation with a 2-wk
follow up period. If the acute lethality endpoint were used
to set exposure standards, appropriate uncertainty, extrapolation
or safety factors would be applied to values determined
in experimental animals.

Но в случаях с введением веществ ингаляционным путем (или путем вдыхания)применяют именно понятие концентрации в качестве дозы ( а как иначе измерить вдыхаемую дозу - только путем учета концентрации):
http://hes.pbh.med.kyoto-u.ac.jp/pfcreview/PEN_09004a2f80006...
Telomer B:
Inhalation ALC: 6 mg/L in rats
Oral LD50: >17,000 mg/kg in rats
Telomer B is not a skin irritant, is untested for eye
irritancy, and is not a skin sensitizer in animals. A
single inhalation exposure produced labored respiration,
weight loss, salivation, and prostration. A single
ingestion exposure produced labored respiration, weight
loss, and prostration.

http://www.tedpella.com/msds_html/81500msd.htm
Results of component toxicity test performed: (Oral Acute ALD (Approximate Lethal Dose), Rats): >1500 mg/kg. (Inhalation ALC, Rats): 4 hr: 383,000 ppm.

Ann Nosova
United States
Local time: 18:36
Specializes in field
Native speaker of: Native in RussianRussian, Native in UkrainianUkrainian
PRO pts in category: 409
Grading comment
Большое спасибо.
Столько ссылок...

Peer comments on this answer (and responses from the answerer)
disagree  Natalie: Секундочку! Летальная концентрация и летальная доза - разные вещи! Концентрация - это содержание вещества в воздухе, воде итп, а доза - то количество веществе, которое попадает в организм - как можно предлагать это в виде синонимов?
2 hrs
  -> thank you, please see the note
Login to enter a peer comment (or grade)




Reference comments


2 hrs peer agreement (net): +1
Reference: -

Reference information:
Не знаю, есть ли необходимость в этой информации, но может пригодится: http://stroy.dbases.ru/Data1/47/47810/index.htm
См. Данные о токсичности галоидоуглеводородов из стандарта США (НФПА 2001), там все эти аббревиатуры в сноске

stasbetman
Ukraine
Native speaker of: Native in RussianRussian, Native in UkrainianUkrainian
PRO pts in category: 16

Peer comments on this reference comment (and responses from the reference poster)
agree  Ann Nosova: очень хорошая ссылка - а оставлять надо аббревиатуру в оригинале - можно разъяснить в скобках - а если написать ПЛК, Бог знает, что можно подумать...
46 mins
  -> спасибо
Login to enter a peer comment (or grade)

6 hrs
Reference: Разъяснение

Reference information:
Acute toxicity (usually just 'toxicity') is measured in two common ways, the Approximate Lethal Concentration (ALC) or the LC50. The ALC is a measure of the level at which lethal effects may begin to occur, while the LC50 is determined as the concentration that kills 50% of test animals (during the time specified for the test). The ALC is therefor a more conservative or safer estimate of the toxicity of a gas.
http://www.orionsafety.com.au/product/triodide/paper1.html

Natalie
Poland
Specializes in field
Native speaker of: Native in RussianRussian
PRO pts in category: 4545
Login to enter a peer comment (or grade)




Return to KudoZ list


Changes made by editors
Apr 20, 2009 - Changes made by Natalie:
Created KOG entryKudoZ term » KOG term


KudoZ™ translation help
The KudoZ network provides a framework for translators and others to assist each other with translations or explanations of terms and short phrases.



See also:



Term search
  • All of ProZ.com
  • Term search
  • Jobs
  • Forums
  • Multiple search