ALC
Russian translation: Минимальная летальная концентрация
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| 16:18 Feb 14, 2009 |
| English to Russian translations [PRO] Medical - Medical (general) / MSDS | |||||||
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|  Selected response from: Ann Nosova United States Local time: 06:51 | ||||||
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| 3 -1 | Минимальная летальная концентрация/доза |
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| Разъяснение |
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| Discussion entries: 6 | |
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Answers
4 hrs confidence: 
peer agreement (net): -1
peer agreement (net): -1| alc Минимальная летальная концентрация/доза Explanation: Да, судя по ссылкам, все так и есть. Однако в русскоязычных статьях, увы, практически не встречается, что и понятно (на слух странно воспринимается "приблизительная смертельная/летальная концентрация/доза)". http://www.inchem.org/documents/eintro/eintro/abreviat.htm ALC approximate lethal concentration ALD approximate lethal dose На основании ниже приведенной ссылки: http://www3.interscience.wiley.com/journal/112227859/abstrac... The approximiate lethal dose (ALD) to rats following oral administration of nine chemicals was determined. The ALD (lowest dose at which death was produced) for each chemical was used to define the general order of toxicity as being either extremely, highly, moderately, slightly, or practically non-toxic. For each of the nine chemicals tested, the category indicated by the ALD was identical with the category determined in the more extensive LD50 studies. In this study, an average of 6.8 rats was needed to determine the ALD while an average of 56.3 rats was needed to determine the LD50. http://dic.academic.ru/dic.nsf/enc_medicine/11239/Доза До́за смерте́льная минима́льная (DLM; d. letalis minima) — Д., вызывающая за фиксированный период времени гибель единичных, наиболее чувствительных подопытных животных; принимается за нижний предел Д. с. -------------------------------------------------- Note added at 12 hrs (2009-02-15 04:36:30 GMT) -------------------------------------------------- Учитывая вопрос, в котором указан ингаляционный путь введения вещества, можно воспользоваться следующими определениями: http://orgchem.colorado.edu/safety/tox.html Hazards of Chemicals: Toxicology Nomenclature LD and LC LD50 is lethal dose 50. This is the single dose of a toxic substance administered by any route (other than by inhalation) that causes the death of 50% of an animal population. LDLo is lethal dose low—the lowest dose of a substance reported to have caused death in humans or animals. LC50 is lethal concentration 50. It is the concentration of a material in air that kills 50% of a group of test animals when administered as a single exposure in a specific time period (usually 1 hour). Note that lethal concentration values are used when the route of administration is by inhalation (rather than oral, dermal, etc.) whereas LD values are used for all routes except inhalation. LC values are often expressed as parts of material per million parts of air (ppm). В других случаях определения тоже практически идентичны: http://www.bugwood.org/PAT/Glossary.html Approximate Lethal Concentration (ALC) – An estimate of the concentration of a pesticide in air or water which is capable of killing a test animal. See also… MLC Approximate Lethal Dose (ALD) – An estimate of the dose of a pesticide which is necessary to kill a test animal. See also… MLD Хотя, конечно, следует учитывать экспозицию: http://refrigerants.dupont.com/Suva/en_US/pdf/k05740.pdf The Approximate Lethal Concentration (ALC) and the Lethal Concentration in “x” percent (LCx) tests in laboratory animals are often used to assess acute lethality. During the ALC or LCx tests, the animals are monitored for any clinical signs that might signal adverse effects in the test animals, including irritation, behavioral changes, anesthetic effects etc. The test typically includes a 4-hr inhalation with a 2-wk follow up period. If the acute lethality endpoint were used to set exposure standards, appropriate uncertainty, extrapolation or safety factors would be applied to values determined in experimental animals. Но в случаях с введением веществ ингаляционным путем (или путем вдыхания)применяют именно понятие концентрации в качестве дозы ( а как иначе измерить вдыхаемую дозу - только путем учета концентрации): http://hes.pbh.med.kyoto-u.ac.jp/pfcreview/PEN_09004a2f80006... Telomer B: Inhalation ALC: 6 mg/L in rats Oral LD50: >17,000 mg/kg in rats Telomer B is not a skin irritant, is untested for eye irritancy, and is not a skin sensitizer in animals. A single inhalation exposure produced labored respiration, weight loss, salivation, and prostration. A single ingestion exposure produced labored respiration, weight loss, and prostration. http://www.tedpella.com/msds_html/81500msd.htm Results of component toxicity test performed: (Oral Acute ALD (Approximate Lethal Dose), Rats): >1500 mg/kg. (Inhalation ALC, Rats): 4 hr: 383,000 ppm. |
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Reference comments
2 hrs peer agreement (net): +1 |
| Reference: - Reference information: Не знаю, есть ли необходимость в этой информации, но может пригодится: http://stroy.dbases.ru/Data1/47/47810/index.htm См. Данные о токсичности галоидоуглеводородов из стандарта США (НФПА 2001), там все эти аббревиатуры в сноске |
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6 hrs |
| Reference: Разъяснение Reference information: Acute toxicity (usually just 'toxicity') is measured in two common ways, the Approximate Lethal Concentration (ALC) or the LC50. The ALC is a measure of the level at which lethal effects may begin to occur, while the LC50 is determined as the concentration that kills 50% of test animals (during the time specified for the test). The ALC is therefor a more conservative or safer estimate of the toxicity of a gas. http://www.orionsafety.com.au/product/triodide/paper1.html |
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