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English to Slovak translations [PRO]
Medical - Chemistry; Chem Sci/Eng | | English term or phrase: slow-tight-binding inhibition | The kinetics of slow-binding and slow, tight-binding inhibition: the effects of substrate depletion.
Powerful enzyme inhibitors are increasingly important, both for
the information they provide about enzyme mechanisms and for
their medical importance. However, the characterization of such
inhibitors is often less than straightforward. The inhibition
characteristically sets in during the course of the assay; the initial rate is not easy to measure: this is slow-binding inhibition.
Moreover, powerful inhibitors are effective at low concentrations.
Thus it may be necessary to use concentrations of the inhibitor
that are comparable with the concentration of enzyme. Then it is
no longer possible to ignore the depletion of the concentration of
unbound inhibitor: the enzyme-inhibitor complex is present at
concentrations comparable with that of the unbound enzyme.
This is tight-binding inhibition. The two features mentioned
often occur together: this is slow, tight-binding inhibition (Morrison, 1982; Morrison and Walsh, 1988).
(prosím, ak sa dá, uveďte citáciu) |
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