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peptabody

Spanish translation: molécula pentamérica de unión multivalente (peptabody)

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17:41 Nov 28, 2009

English to Spanish translations [PRO]
Science - Biology (-tech,-chem,micro-)

English term or phrase: peptabody

"a new type of high avidity binding molecule, termed peptabody, created by harnessing the effect of multivalent interaction"

Roberto Sanders KudoZ activity Questions: 44 (2 open) (3 without valid answers) (1 closed without grading) Answers: 38 Spain
Local time: 02:48

Spanish translation:molécula pentamérica de unión multivalente (peptabody)

Explanation:
Peptabody no es lo mismo que peptibody (pepticuerpo). A lo mejor, por analogía podría traducirse como peptacuerpo, pero no hay ninguna referencia al respecto.

“Peptabody”: A new type of high avidity binding protein — PNAS
A new type of high avidity binding molecule, termed “peptabody” was created by harnessing the effect of multivalent interaction. A short peptide ligand was ...
www.pnas.org/content/94/5/1663.full

Peptibodies: the new cool technology - Elsevier - [ Traducir esta página ]
Now, a hybrid of the two has been created – the peptibody. ... Ken Wild unveiled the company's development of an analgesic peptibody targeted to nerve ...
linkinghub.elsevier.com/retrieve/pii/S1359644604032167

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Note added at 56 mins (2009-11-28 18:38:52 GMT)
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Peptabody - Med Discovery SA - The Onco-Urology Company - [ Traducir esta página ]
The peptabody technology is designed to allow pentamerization of polypeptide ligands and hence strong, cooperative target binding. ...
med-discovery.webcreatif.net/.../Standard.aspx?id_page... -

http://www.ncbi.nlm.nih.gov/pubmed/16858684

Patent 6350860 - [ Traducir esta página ]
The present invention further aims at providing a multivalent antibody chosen from the group consisting of triabodies, tetravalent antibodies, peptabodies ...
www.pharmcast.com/.../6350860_Interferon022602.htm

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Note added at 15 hrs (2009-11-29 08:55:53 GMT)
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Para que quede claro lo que son peptabodies y peptibodies (pepticuerpos):

Peptabodies:

Preferably, the oligomers are peptabodies (Terskikh et al., Biochemistry 94:1663-1668 (1997)). Peptabodies can be exemplified as IgM antibodies which are pentameric with each binding site having low-affinity binding, but able to bind in a high affinity manner as a complex. Peptabodies are made using phage-displayed random peptide libraries. A short peptide ligand from the library is fused via a semi-rigid hinge at the N-terminus of the COMP (cartilage oligomeric matrix protein) pentamerization domain. The fusion protein is expressed in bacteria where it assembles into a pentameric antibody which shows high affinity for its target. Depending on the affinity of the ligand, an antibody with very high affinity can be produced.
http://www.freepatentsonline.com/7265212.html

Peptibodies:
Developed by Amgen, peptibodies are engineered therapeutic molecules that can bind to human drug targets and contain peptides linked to the constant domains of antibodies.

http://www.drugs.com/nda/romiplostim_080312.html