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Medical - Biology (-tech,-chem,micro-) | | English term or phrase: mechanistically unique PR antagonists | Estoy traduciendo un artículo sobre antagonistas del receptor de la progesterona.
"PR ligands can be classified into either of three mechanistically distinct groups
As an initial step in this study, we screened a series of steroidal PR ligands to identify compounds that displayed
agonist, antagonist, or mixed agonist activity on PR. It was anticipated that this would allow the identification of **mechanistically unique PR antagonists** that could function as dissociated antiprogestins or which could serve as leads for additional synthetic chemistry."
¿antagonistas de los receptores de la progesterona con mecanismos de acción únicos?
Gracias nuevamente |
| | | Spanish translation:antagonistas del receptor de la progesterona con un mecanismo de acción pârticular | Explanation:
(O algo por el estilo.) Es decir, sustancias cuya acción antagonista se ejerce a través de un mecanismo singular con respecto al resto de los antagonistas.
En estos casos, lo usual es hablar de "el receptor" en singular (es decir, la entidad).
Saludos.
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Note added at 2 días6 horas (2012-01-15 09:23:37 GMT) Post-grading
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De nada, Yvonne. |
| Selected response from:
M. C. Filgueira
Local time: 20:08
| Grading comment Muchísimas gracias
4 KudoZ points were awarded for this answer |
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| Discussion entries: 0 |
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Automatic update in 00:
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8 mins confidence:   | mechanistically unique pr antagonists antagonistas PR (no sé que significa) únicos en cuanto a su mecanicidad
Explanation:
Estoy seguro
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Note added at 8 minutos (2012-01-13 03:15:32 GMT)
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¿Qué significa PR?
| | | Notes to answerer
Asker: PR = progesterone receptors. Disculpa que no lo haya indicado en la consulta
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14 hrs confidence: | mechanistically unique pr antagonists PRA únicos en lo que respecta a la mecánica (molecular)
Explanation:
"Antagonistas de Receptores de Progesterona únicos en lo que respecta a la mecánica (molecular)"
"Mecánica molecular" o "Dinámica molecular" entendida como interacción/movimiento/unión entre partículas y los efectos consiguientes (efectos agonistas o antagonistas).
"También es posible correlacionar energías totales de unión, calculadas sobre los complejos ligando-receptor, generalmente mediante mecánica molecular"
http://books.google.es/books?id=-SozhUVs8f4C&pg=PA1755&lpg=P...
"The results of this analysis confirm that
hPR ligands can be separated into three mechanistically
distinct groups likely representing agonists, antagonists, and a
third class for which the biological activity could not be
predicted using this assay.
It was important to determine whether or not the three
mechanistically distinct ligands would manifest unique activities when assayed in a bonafide progesterone target cell."
http://www.pnas.org/content/93/16/8739.full.pdf
"En tal sentido se han identificado tres categorías de ligandos con efectos radicalmente diferentes: agonistas (como el Diazepam y otros ansiolíticos)"
http://www.javeriana.edu.co/Facultades/Ciencias/neurobioquim...
"Asociación molecular: principales eventos .... a) basadas en campos de fuerzas de mecánica molecular .... Agonistas del receptor mGlu4 "
http://novacripta.cbm.uam.es/bioweb/courses/UFV0506/tema10/c...
Espero que esta información te resulte útil. Un saludo.
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The translation workplace 
