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Medical - Biology (-tech,-chem,micro-) | | English term or phrase: ER-mixed agonists | Estoy traduciendo un artículo sobre antagonistas del receptor de la progesterona.
"It has previously been determined that the activity of the **ER-mixed agonist** tamoxifen is influenced by cell and promoter context (ref). In light of this, we decided to examine whether or not the partial agonist activity of RTI-020, -021, and -022 was likewise affected by the context in which it was assayed. To address this issue we evaluated the pharmacology of the PR-mixed agonists on a transfected MMTV promoter in PR-containing T47D cells and compared it to that of the pure agonists and antagonists."
PR = progesterone receptor
Pienso que ER = estrogen receptor
MMTV = mouse mammary tumor virus
Muchas gracias por su ayuda |
| | | Spanish translation:agonistas mixtos de los receptores de estrógeno | Explanation:
Exactamente. El tamoxifeno funciona como antagonista de los receptores de estrógeno en el tejido de los senos, pero funciona como agonista en el tejido endométrico. |
| Selected response from:
 Alistair Ian Spearing Ortiz
Local time: 20:08
| Grading comment Muchas gracias
4 KudoZ points were awarded for this answer |
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| Discussion entries: 0 |
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Automatic update in 00:
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58 mins confidence:   | er-mixed agonists agonistas mixtos de los receptores de estrógeno
Explanation:
Exactamente. El tamoxifeno funciona como antagonista de los receptores de estrógeno en el tejido de los senos, pero funciona como agonista en el tejido endométrico.
| | | | Notes to answerer
Asker: Mil gracias. Me tenía confundida el guión
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