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broad spectrum and high affinity binding of

Spanish translation: amplio espectro y alta afinidad de unión de [los ligandos ErbB]

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12:03 Jan 16, 2012

English to Spanish translations [PRO]
Science - Biology (-tech,-chem,micro-)

English term or phrase: broad spectrum and high affinity binding of

muchas gracias!

Gabriel R KudoZ activity Questions: 262 (2 open) (1 closed without grading) Answers: 0
Local time: 15:08

Spanish translation:amplio espectro y alta afinidad de unión de [los ligandos ErbB]

Explanation:
Mi sugerencia.

"El cambio en la secuencia de aminoácidos de un tipo de receptor a otro se puede realizar en cualquier punto apropiado que posibilite un amplio espectro y alta afinidad de unión de los ligandos ErbB."

Selected response from:

Alistair Ian Spearing Ortiz
Local time: 20:08

Grading comment

GRACIAS
4 KudoZ points were awarded for this answer

Summary of answers provided

5 +1

amplio espectro y alta afinidad de unión de [los ligandos ErbB]

Alistair Ian Spearing Ortiz

4 -1

cualquier ubicación apta que permita a los ligandos ErbB una unión de amplio espectro y de alta afin

Carl Stoll

Answers

5 mins confidence:

peer agreement (net): +1

amplio espectro y alta afinidad de unión de [los ligandos ErbB]

Alistair Ian Spearing Ortiz
Local time: 20:08
Specializes in field
Native speaker of:

Spanish,

English
PRO pts in category: 102

Grading comment

GRACIAS

11 hrs confidence:

peer agreement (net): -1

any suitable location that provides for broad spectrum and high affinity binding of ErbB ligands cualquier ubicación apta que permita a los ligandos ErbB una unión de amplio espectro y de alta afin

Explanation:
No soy ducho en la terminología de este campo. Por consiguiente le copié la terminología al que respondió primero. En cambio la sintaxis de la respuesta ofrecida es inaceptable, ya que reproduce la sintaxis inglesa, que en español suena forzada e indigesta. Mi propuesta es más castellana.

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Note added at 11 horas (2012-01-16 23:43:37 GMT)
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También "alta afinidad" es extranjerismo. En español solemos decir "gran afinidad" o "pronunciada afinidad" o algo por el estilo.

Carl Stoll
United States
Local time: 13:08
Works in field
Native speaker of:

English,

Spanish

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Changes made by editors

Jan 27 - Changes made by Yana Dovgopol:
Term Context	[24] The switch in the amino acid sequence from one receptor type to another can be at any suitable location that provides for broad spectrum and high affinity binding of ErbB ligands. In some embodiments the switch can occur in the SI sub-domain which links LI and Lll sub-domains. In some embodiments the switch will occur in regions where amino acid sequences are homologous or identical between the receptors being combined, such as in module 5 of the SI sub-domain. [24] Surprisingly, it has been found that portions of the amino acid sequence of ErbB3 or ErbB4 can be combined with portions of ErbBl through an SI linking domain to create a chimeric binding molecule that binds ligands to both of the combined receptors. Thus, the combination of ErbBl and ErbB4 domains can be used to produce a chimeric binding molecule that has affinity for both heregulin (ErbB4 specific ligand) and TGFa (ErbBl specific ligand). [25] For purposes of this disclosure the term \"homology\" is intended to mean a region of amino acid sequence having identical or conservative amino acid substitutions as that term is generally understood in the art. For example with respect to an ErbB4/ErbBl chimera, as shown in Figure 3, a switch from the ErbB4 to the ErbBl sequence can take place in module 5 of the SI sub-domain such that the sequence ending in VYNP from the ErbB4 sequence is followed by TTYQ from the ErbBl sequence, as shown by the highlighted sequence in Figure 3. muchas gracias! => muchas gracias!
Jan 16 - Changes made by Alistair Ian Spearing Ortiz:
Field (specific)	Chemistry; Chem Sci/Eng => Biology (-tech,-chem,micro-)

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broad spectrum and high affinity binding of

Spanish translation: amplio espectro y alta afinidad de unión de [los ligandos ErbB]

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broad spectrum and high affinity binding of

Spanish translation: amplio espectro y alta afinidad de unión de [los ligandos ErbB]

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KudoZ™ translation helpThe KudoZ network provides a framework for translators and others to assist each other with translations or explanations of terms and short phrases.

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