Dice 05:58 Feb 3
After oral intake in women, mifepristone is immediately and extensively metabolized by demethylation of the aromatic dimethylaminophenyl side chain at C-11 and hydroxylation of the 17a-propynyl group. The three **most proximal metabolites**, namely, the N-mono- and didemethylated and hydroxylated products of mifepristone all retain considerable affinity toward the human progestin and glucocorticoid receptors, and circulate at serum concentrations comparable to the parent compound." | 
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