was flashed on silica until product eluted

Spanish translation: se adsorbió en gel de sílice hasta la extracción/separación del producto

13:24 Jul 3, 2007

English to Spanish translations [PRO]
Medical - Chemistry; Chem Sci/Eng

English term or phrase: was flashed on silica until product eluted

En una patente farmacéutica, específicamente en la sección de descripción de las reacciones:

"The reaction mixture was then cooled to 0°C. NaI (1.60 g, 10.7 mmol) was added, and then a solution of freshly prepared tert-butyl bis(2-chloroethyl)carbamate (2.58 g, 10.7 mmol) in DMF (10 mL) was added by syringe. The reaction mixture was warmed to room temperature and stirred overnight (19 hours). The reaction mixture was poured into ice saturated NH4Cl, and the mixture was extracted with EtOAc. The combined extracts were dried (Na2SO4), filtered, and concentrated. The crude **was flashed on silica** (Biotage 40L, 9:1 hex:EtOAc **until product eluted**, then 6:1 hex:EtOAc to elute product) to give tert-butyl 4-(4-chloro-3-fluorophenyl)-4-cyanopiperidine-1-carboxylate (1.96 g, 54.2% yield) as a yellow oil. LC/MS (APCI+) m/z 239 [M-Boc+H]+."

Quisiera confirmar si esto significa que "se sometió a cromatografía flash hasta que eluyera producto". Mi principal duda se refiere al "flash" como verbo aquí. En vista de que en patentes anteriores de estos mismos autores ellos hablaban de flash chromatography, pienso que "flash" podría traducirse como "se sometió a cromatografía flash"

Yvonne Becker KudoZ activity Questions: 4265 (2 open) (3 without valid answers) (73 closed without grading) Answers: 2174
Local time: 17:05

Spanish translation:se adsorbió en gel de sílice hasta la extracción/separación del producto

Explanation:
No creo que "flash" tenga nada que ver con cromatografía flash aquí. Se trata de una operación de extracción, separación de dos componentes, con lo que creo que el gel de sílice sirve como soprte para separar los componentes.

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Note added at 1 hr (2007-07-03 14:38:30 GMT)
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... rodamina B, adsorbido sobre una superficie de gel de sílice activada. ... C) Residuo básico : Aminas, hidrocarburos aromáticos N-heterocíclicos ...
http://www.uclm.es/profesorado/jmlemus/TEMA6.ppt

Generalmente se presenta en sobres donde el etanol está adsorbido a gel de sílice liberándose gradualmente a través de las paredes del mismo cuya ...
http://www.ikxur.com/01ed5595c61135e05.html

Selected response from:

Juan Luis
Local time: 23:05

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se adsorbió en gel de sílice hasta la extracción/separación del producto

Juan Luis

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se adsorbió en gel de sílice hasta la extracción/separación del producto

Juan Luis
Local time: 23:05
Specializes in field
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Catalan
PRO pts in category: 23

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Gracias

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was flashed on silica until product eluted

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