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English to Spanish translations [PRO]
Chemistry; Chem Sci/Eng | | English term or phrase: delayed match to position test | | GRACIAS! |
| Gabriel RKudoZ activityQuestions: 262 ( 2 open) ( 1 closed without grading) Answers: 0
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| | Selected response from:
 Marjon Pijl
Local time: 05:54
| Grading comment gracias
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| Changes made by editors |
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| Jan 27 - Changes made by Yana Dovgopol: | | Term Context | In vitro, RO4917523 has been shown to be a potent mGlu5 receptor antagonist (Kd of 0.8 nM for human mGlu5 receptors). When RO4917523 was tested for activity on other relevant targets (over 100), it exhibited over 1000 fold lower activity at all targets including receptors, enzymes and ion channels. In animal models of anxiety, RO4917523 elicits dose-dependent anxiolytic effects in the Stress Induced Hyperthermia (SIH) model in mice, in the Vogel Conflict Test in rats, the Fear Potentiated Startle response in rats, and in the Conditioned Emotional Response (CER) tests in rats. Furthermore, RO4917523 was also active in animal models used to detect antidepressant potential such as the forced swim test and the stress-induced anhedonia test. In sleep studies, RO4917523 induced an increase in non-REM:REM ratio supportive of an anti-depressant-like profile. RO4917523 did not potentiate the effects of ethanol in mice and had no cognitive impairing activity in the delayed match to position test in rats. However, RO4917523 impaired performance in the Morris water maze in two different protocols at doses above 0.1 mg/kg p.o. at 4 h post-administration.
GRACIAS! => GRACIAS! | | Jan 15 - Changes made by Marjon Pijl: | | Created KOG entry | KudoZ term => KOG term |
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