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English to Spanish translations [PRO]
Science - Chemistry; Chem Sci/Eng | | English term or phrase: aromatic A-ring derivatives of | En un artículo titulado "In vitro antiprogestational/antiglucocorticoid activity and progestin and glucocorticoid receptor binding of the putative metabolites and synthetic derivatives of CDB-2914, CDB-4124, and mifepristone" (Actividad antiprogestacional / antiglucocorticoide in vitro y unión al receptor de progesterona y glucocorticoides de los metabolitos putativos y derivados sintéticos del CDB-2914, CDB-4124 y la mifepristona):
"We have examined the functional activities and potencies, in various cell-based assays, and relative binding affinities (RBAs) for progesterone receptors (PR) and glucocorticoid receptors (GR) of the putative mono- and didemethylated metabolites of CDB-2914, CDB-4124, and mifepristone and of the 17α-hydroxy and **aromatic A-ring derivatives of** CDB-2914 and CDB-4124. The binding affinities of the monodemethylated metabolites for rabbit uterine PR and human PR-A and PR-B were similar to those of the parent compounds. "
Aromatic ring = anillo aromático y derivatives = derivados, pero desconozco a qué se refiere la "A" en este caso.
Muchas gracias por sus sugerencias |
|  Yvonne BeckerKudoZ activityQuestions: 3285 ( 5 open) ( 1 without valid answers) ( 64 closed without grading) Answers: 2086
| | Local time: 23:25
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| | derivados de [...] con el anillo A aromático | Explanation:
Se deduce del contexto que los compuestos CDB-2914 y CDB-4124 tienen un núcleo ciclopentanoperhidrofenantrénico en el que el anillo A no es aromático. Los derivados en cuestián deben obtenerse por acción de la aromatasa.
Saludos cordiales.
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Note added at 28 minutos (2012-01-28 03:21:44 GMT)
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Acá podés ver cómo es el esqueleto de los esteroides y cómo se designan los cuatro anillos (A, B, C y D):
http://www.people.vcu.edu/~urdesai/intro.htm |
| Selected response from:
M. C. Filgueira
Local time: 05:55
| Grading comment Muchas gracias
4 KudoZ points were awarded for this answer |
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| Discussion entries: 0 |
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Automatic update in 00:
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20 mins confidence:  | aromatic a-ring derivatives of derivados de [...] con el anillo A aromático
Explanation:
Se deduce del contexto que los compuestos CDB-2914 y CDB-4124 tienen un núcleo ciclopentanoperhidrofenantrénico en el que el anillo A no es aromático. Los derivados en cuestián deben obtenerse por acción de la aromatasa.
Saludos cordiales.
--------------------------------------------------
Note added at 28 minutos (2012-01-28 03:21:44 GMT)
--------------------------------------------------
Acá podés ver cómo es el esqueleto de los esteroides y cómo se designan los cuatro anillos (A, B, C y D):
http://www.people.vcu.edu/~urdesai/intro.htm
| M. C. Filgueira
Local time: 05:55
Specializes in field
Native speaker of:  Spanish
PRO pts in category: 794
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