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spines arrested in premature morphology

Spanish translation: espinas [sinápticas] detenidas en una morfología prematura


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11:00 Jan 10, 2012
English to Spanish translations [PRO]
Medical - Medical: Pharmaceuticals
English term or phrase: spines arrested in premature morphology
muchas gracias!!!
Gabriel R
Local time: 13:02
Spanish translation:espinas [sinápticas] detenidas en una morfología prematura
Explanation:
.
Selected response from:

Mercedes Marta Moreno
Local time: 18:02
Grading comment
Gracias :)
4 KudoZ points were awarded for this answer



Summary of answers provided
3 +3espinas [sinápticas] detenidas en una morfología prematura
Mercedes Marta Moreno


  

Answers


21 mins   confidence: Answerer confidence 3/5Answerer confidence 3/5 peer agreement (net): +3
espinas [sinápticas] detenidas en una morfología prematura


Explanation:
.

Mercedes Marta Moreno
Local time: 18:02
Native speaker of: Native in SpanishSpanish
PRO pts in category: 32
Grading comment
Gracias :)

Peer comments on this answer (and responses from the answerer)
agree  Alistair Ian Spearing Ortiz: Sip.
5 mins
  -> Thanks Alistair.
agree  isabel murillo: eso es
8 mins
  -> Gracias Isabel.
agree  Lourdes Sanchez
3 hrs
  -> Gracias Lourdes.
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Changes made by editors
Jan 27 - Changes made by Yana Dovgopol:
Term ContextMetabotropic glutamate receptors play a role in a wide variety of neuronal functions. Exaggerated mGlu5 signaling may account for the cognitive impairment and other clinical symptoms associated with FXS. Preclinical data supports this mGlu5 theory and suggests there is a ‘rescue’ of several phenotypes of the Fragile X disease model based upon a decrease in mGlu5 receptor functioning either by administration of an mGlu5 antagonist or a decrease in the abundance of receptors. Studies with the mGlu5 antagonists MPEP (2-Methyl-6-(phenylethynyl)-pyridine) [10] and fenobam [17] have demonstrated that acute inhibition of the mGlu5 receptor in adult FMR1 knockout mice leads to an improvement of various deficits that closely correlate to symptoms in FXS patients. In contrast to the studies with antagonists, the reduction of mGlu5 receptor levels resembles a 50% receptor inhibition throughout the entire development of the FMR1 knock-out mice. The reduction of mGlu5 receptor levels by 50% in FMR1 knockout mice revealed a complete recovery of all phenotypes examined except macroorchidism [11], including: • Full rescue of deficient development of cortical plasticity in the FMR1 knockout (i.e., development of ocular dominance columns in the visual cortex) • Full rescue of deficient morphology of synaptic spines in the FMR1 knockout (i.e., increased total number and increased fraction of spines arrested in premature morphology) • Full correction of increased overall, basal rate of neuronal protein biosynthesis in the Fmr1 knockout • Full rescue of an exaggerated inhibitory avoidance extinction in the FMR1 knockout muchas gracias!!! => muchas gracias!!!


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