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The most serious human health effect of rapid and excessive copper intake from drinking water is short-term stomach upset and/or diarrhea. This upset is caused when high concentrations of copper irritate the lining of the stomach. To protect against these ailments, the US Environmental Protection Agency (EPA) has set a guidance level for the US limiting copper in drinking water to 1.3 mg/L (parts per million). The World Health Organization, an organization that many countries of the world rely upon for health guidance, has established a 2 mg/L copper guidance level. Literature and ongoing research indicate that both of these guidance levels are protective of human health.