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Science - Biology (-tech,-chem,micro-)
Additional field(s): Medical (general), Genetics | | English term or phrase: gene silencing | Definition from MedicineNet, Inc. :
Gene silencing: A mechanism by which cells shut down large sections of chromosomal DNA. Gene silencing is done by incorporating the DNA to be silenced into a form of DNA called heterochromatin that is already silent.
The process of gene silencing is important for the differentiation of many different types of cells.
Example sentence(s): - Evidence is emerging that geminiviruses and plant pararetroviruses can interact with the gene silencing system either from introduced DNA constructs or during viral pathogenesis. Some observations suggest there are complex relationships between DNA viral activity, transcriptional and post-transcriptional gene silencing mechanisms. biotech-info.net
- The biggest challenges in the field at the moment are understanding two things: how does DNA methylation participate in gene silencing (and that includes what molecules target the DNA methylation to these promoter regions), and why is the cancer cell doing this? The Thomson Corporation
- In 2005, Pikaard and his collaborators published research showing that the major function of Pol IV is to generate siRNAs, thereby singling out this RNA polymerase as a potential player in gene silencing. ScienceDaily LLC
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| genavstängning | Definition:
När en gen tystas ned, genom t.ex. RNA-interferens, talar man på svenska om genavstängning (gene silencing). Hos växter som används som livsmedel kan man blockera eller reducera bildningen av oönskade ämnen, till exempel sådana som kan framkalla allergi. Djurmodeller av vissa sjukdomar, till exempel högt blodkolesterolvärde, kan påverkas gynnsamt genom genavstängning. I en klinisk prövning använder man RNA-interferens för att blockera en gen som är verksam vid en näthinnesjukdom. |
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  Gabriella Jönsson
Sweden
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peer agreement (net): +3
